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Identification of Adenovirus Species in Iranian Pediatric Population With Severe Acute Respiratory Infections Publisher



Shafieijandaghi NZ1 ; Yavarian J1 ; Malekshahi SS2 ; Naseri M1 ; Shadab A1 ; Ghavami N1 ; Mokhtariazad T1
Authors

Source: Future Virology Published:2019


Abstract

Aim: In this study we aimed to find the rate of human adenovirus (HAdV) infections and identify HAdVs molecular epidemiology in children younger than 5 years old with clinical diagnosis of severe acute respiratory infections in Iran. Patients & methods: A semi-nested PCR with in-house designed primers for HAdV was performed on 200 oropharyngeal swabs collected within 5 days from the onset of symptoms. The positive samples were subjected to sequencing and a phylogenetic tree was drawn. Results: Out of 200 specimens, 71 (35.5%) cases were positive for HAdVs. Detected strains matched with HAdV species B (80.3%), C (15.5%), D (2.8%) and E (1.8%). HAdV- B14/55 and HAdV-B3 were the most prevalent types, respectively. Conclusion: This study showed that infections with HAdV species B, were common in children, who were clinically diagnosed as severe acute respiratory infection cases in Iran. The results could be useful for future epidemiological researches. © 2019 Future Medicine Ltd.
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