Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
A Preliminary Study of Microrna-208B After Acute Myocardial Infarction: Impact on 6-Month Survival Publisher Pubmed



Alavimoghaddam M1, 2 ; Chehrazi M3 ; Alipoor SD4 ; Mohammadi M1 ; Baratloo A5 ; Mahjoub MP6 ; Movasaghi M7 ; Garssen J8, 9 ; Adcock IM10, 11 ; Mortaz E7, 12
Authors

Source: Disease Markers Published:2018


Abstract

Introduction. miRNAs contribute to a variety of essential biological processes including development, proliferation, differentiation, and apoptosis. Circulating microRNAs are very stable and have shown potential as biomarkers of cardiovascular disease. microRNA-208b expression was increased in the blood of patients with acute myocardial infarction (AMI) and has been proposed as a biomarker for early diagnosis. In this pilot study, we investigate the potential of circulating miR-208b as a prognostic biomarker of 6-month survival in AMI patients. Methods. Plasma samples from 21 patients and 8 age- and gender-matched healthy adults were collected, and circulating levels of miR-208b were detected using quantitative real-time PCR. Results. miR-208b levels were higher in healthy control subjects (9.6-fold; P ≤ 0 05). Within the AMI patients, the levels of miR-208b were significantly lower in the survivor versus nonsurvivor group (fold change = 6.51 and 14.1, resp.; P ≤ 0 05). The Kaplan-Meier curve revealed that the 6-month survival time was significantly higher among AMI patients with a relative expression of miR-208b lower than 12.38. The hazard ratio (HR) for the relative expression of miR-208b (<12.38 was the reference) was 5.08 (95% CI: 1.13–22.82; P = 0 03). Conclusion. Our results showed that elevated miR-208b expression was associated with reduced long-term survival in AMI patients. These pilot data indicate the need for a large follow-up study to confirm whether miR-208b can be used as a predictor of 6-month survival time after AMI. Copyright © 2018 Mostafa Alavi-Moghaddam et al.
Other Related Docs
8. Circulating Mirna-106B-5P As a Potential Biomarker for Coronary Artery Disease, International Journal of Molecular and Cellular Medicine (2024)
13. Altered Mir-223 Expression in Sputum for Diagnosis of Non-Small Cell Lung Cancer, Avicenna Journal of Medical Biotechnology (2017)