A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection

A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection Publisher Pubmed

Fourati S¹ ; Talla A¹ ; Mahmoudian M^{2, 3} ; Burkhart JG^{4, 5} ; Klen R² ; Henao R^{6, 7} ; Yu T⁸ ; Aydin Z⁹ ; Yeung KY¹⁰ ; Ahsen ME¹¹ ; Almugbel R¹⁰ ; Jahandideh S¹² ; Liang X¹⁰ ; Nordling TEM¹³ Show All Authors

Fourati S¹
Talla A¹
Mahmoudian M^{2, 3}
Burkhart JG^{4, 5}
Klen R²
Henao R^{6, 7}
Yu T⁸
Aydin Z⁹
Yeung KY¹⁰
Ahsen ME¹¹
Almugbel R¹⁰
Jahandideh S¹²
Liang X¹⁰
Nordling TEM¹³
Shiga M¹⁴
Stanescu A^{11, 15}
Vogel R^{11, 16}
Abdallah EB^{21, 22}
Aghababazadeh FA²³
Amadoz A²⁴
Bhalla S²⁵
Bleakley K^{26, 27}
Bongen E²⁸
Borzacchielo D^{22, 29}
Bucher P^{30, 31}
Carbonellcaballero J³²
Chaudhary K³³
Chinesta F³⁴
Chodavarapu P³⁵
Chow RD³⁶
Cokelaer T³⁷
Cubuk C³⁸
Dhanda SK³⁹
Dopazo J³⁸
Faux T²
Feng Y⁴⁰
Flinta C⁴¹
Guziolowski C^{21, 22}
He D⁴²
Hidalgo MR³⁸
Hou J⁴³
Inoue K^{44, 45}
Jaakkola MK^{2, 46}
Ji J⁴⁷
Kumar R⁴⁸
Kumar S^{30, 31}
Kursa MB⁴⁹
Li Q^{50, 51}
Lopuszynski M⁴⁹
Lu P⁵¹
Magnin M^{21, 22, 44}
Mao W^{52, 53}
Miannay B²¹
Nikolayeva I^{54, 55, 56}
Obradovic Z⁵⁷
Pak C⁵⁸
Rahman MM¹⁰
Razzaq M^{21, 22}
Ribeiro T^{21, 22, 44}
Roux O^{21, 22}
Saghapour E⁵⁹
Saini H⁶⁰
Sarhadi S⁶¹
Sato H⁶²
Schwikowski B⁵⁴
Sharma A^{63, 64, 65}
Sharma R^{65, 66}
Singla D⁶⁷
Stojkovic I^{57, 68}
Suomi T²
Suprun M⁶⁹
Tian C^{70, 71}
Tomalin LE⁷²
Xie L⁷³
Yu X⁷⁴
Pandey G¹¹
Chiu C¹⁷
Mcclain MT^{6, 18, 19}
Woods CW^{6, 18, 19}
Ginsburg GS^{6, 19}
Elo LL²
Tsalik EL^{6, 19, 20}
Mangravite LM⁸
Sieberts SK⁸

Source: Nature Communications Published:2018

Abstract

The response to respiratory viruses varies substantially between individuals, and there are currently no known molecular predictors from the early stages of infection. Here we conduct a community-based analysis to determine whether pre- or early post-exposure molecular factors could predict physiologic responses to viral exposure. Using peripheral blood gene expression profiles collected from healthy subjects prior to exposure to one of four respiratory viruses (H1N1, H3N2, Rhinovirus, and RSV), as well as up to 24 h following exposure, we find that it is possible to construct models predictive of symptomatic response using profiles even prior to viral exposure. Analysis of predictive gene features reveal little overlap among models; however, in aggregate, these genes are enriched for common pathways. Heme metabolism, the most significantly enriched pathway, is associated with a higher risk of developing symptoms following viral exposure. This study demonstrates that pre-exposure molecular predictors can be identified and improves our understanding of the mechanisms of response to respiratory viruses. © 2018, The Author(s).

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Style	Citing Format
MLA	Fourati S, et al.. "A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection." Nature Communications, vol. 9, no. 1, 2018, pp. -.
APA	Fourati S, Talla A, Mahmoudian M, Burkhart JG, Klen R, Henao R, Yu T, Aydin Z, Yeung KY, Ahsen ME, Almugbel R, Jahandideh S, Liang X, Nordling TEM, Shiga M, Stanescu A, Vogel R, Abdallah EB, Aghababazadeh FA, ... Sieberts SK (2018). A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection. Nature Communications, 9(1), -.
Chicago	Fourati S, Talla A, Mahmoudian M, Burkhart JG, Klen R, Henao R, Yu T, et al.. "A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection." Nature Communications 9, no. 1 (2018): -.
Harvard	Fourati S et al. (2018) 'A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection', Nature Communications, 9(1), pp. -.
Vancouver	Fourati S, Talla A, Mahmoudian M, Burkhart JG, Klen R, Henao R, et al.. A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection. Nature Communications. 2018;9(1):-.
BibTex	@article{ author = {Fourati S and Talla A and Mahmoudian M and Burkhart JG and Klen R and Henao R and Yu T and Aydin Z and Yeung KY and Ahsen ME and Almugbel R and Jahandideh S and Liang X and Nordling TEM and Shiga M and Stanescu A and Vogel R and Abdallah EB and Aghababazadeh FA and Amadoz A and Bhalla S and Bleakley K and Bongen E and Borzacchielo D and Bucher P and Carbonellcaballero J and Chaudhary K and Chinesta F and Chodavarapu P and Chow RD and Cokelaer T and Cubuk C and Dhanda SK and Dopazo J and Faux T and Feng Y and Flinta C and Guziolowski C and He D and Hidalgo MR and Hou J and Inoue K and Jaakkola MK and Ji J and Kumar R and Kumar S and Kursa MB and Li Q and Lopuszynski M and Lu P and Magnin M and Mao W and Miannay B and Nikolayeva I and Obradovic Z and Pak C and Rahman MM and Razzaq M and Ribeiro T and Roux O and Saghapour E and Saini H and Sarhadi S and Sato H and Schwikowski B and Sharma A and Sharma R and Singla D and Stojkovic I and Suomi T and Suprun M and Tian C and Tomalin LE and Xie L and Yu X and Pandey G and Chiu C and Mcclain MT and Woods CW and Ginsburg GS and Elo LL and Tsalik EL and Mangravite LM and Sieberts SK}, title = {A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection}, journal = {Nature Communications}, volume = {9}, number = {1}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Fourati S AU - Talla A AU - Mahmoudian M AU - Burkhart JG AU - Klen R AU - Henao R AU - Yu T AU - Aydin Z AU - Yeung KY AU - Ahsen ME AU - Almugbel R AU - Jahandideh S AU - Liang X AU - Nordling TEM AU - Shiga M AU - Stanescu A AU - Vogel R AU - Abdallah EB AU - Aghababazadeh FA AU - Amadoz A AU - Bhalla S AU - Bleakley K AU - Bongen E AU - Borzacchielo D AU - Bucher P AU - Carbonellcaballero J AU - Chaudhary K AU - Chinesta F AU - Chodavarapu P AU - Chow RD AU - Cokelaer T AU - Cubuk C AU - Dhanda SK AU - Dopazo J AU - Faux T AU - Feng Y AU - Flinta C AU - Guziolowski C AU - He D AU - Hidalgo MR AU - Hou J AU - Inoue K AU - Jaakkola MK AU - Ji J AU - Kumar R AU - Kumar S AU - Kursa MB AU - Li Q AU - Lopuszynski M AU - Lu P AU - Magnin M AU - Mao W AU - Miannay B AU - Nikolayeva I AU - Obradovic Z AU - Pak C AU - Rahman MM AU - Razzaq M AU - Ribeiro T AU - Roux O AU - Saghapour E AU - Saini H AU - Sarhadi S AU - Sato H AU - Schwikowski B AU - Sharma A AU - Sharma R AU - Singla D AU - Stojkovic I AU - Suomi T AU - Suprun M AU - Tian C AU - Tomalin LE AU - Xie L AU - Yu X AU - Pandey G AU - Chiu C AU - Mcclain MT AU - Woods CW AU - Ginsburg GS AU - Elo LL AU - Tsalik EL AU - Mangravite LM AU - Sieberts SK TI - A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection JO - Nature Communications VL - 9 IS - 1 SP - EP - PY - 2018 ER -

Style

Citing Format

MLA

Fourati S, et al.. "A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection." Nature Communications, vol. 9, no. 1, 2018, pp. -.

APA

Fourati S, Talla A, Mahmoudian M, Burkhart JG, Klen R, Henao R, Yu T, Aydin Z, Yeung KY, Ahsen ME, Almugbel R, Jahandideh S, Liang X, Nordling TEM, Shiga M, Stanescu A, Vogel R, Abdallah EB, Aghababazadeh FA, ... Sieberts SK (2018). A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection. Nature Communications, 9(1), -.

Chicago

Fourati S, Talla A, Mahmoudian M, Burkhart JG, Klen R, Henao R, Yu T, et al.. "A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection." Nature Communications 9, no. 1 (2018): -.

Harvard

Fourati S et al. (2018) 'A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection', Nature Communications, 9(1), pp. -.

Vancouver

Fourati S, Talla A, Mahmoudian M, Burkhart JG, Klen R, Henao R, et al.. A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection. Nature Communications. 2018;9(1):-.

BibTex

@article{ author = {Fourati S and Talla A and Mahmoudian M and Burkhart JG and Klen R and Henao R and Yu T and Aydin Z and Yeung KY and Ahsen ME and Almugbel R and Jahandideh S and Liang X and Nordling TEM and Shiga M and Stanescu A and Vogel R and Abdallah EB and Aghababazadeh FA and Amadoz A and Bhalla S and Bleakley K and Bongen E and Borzacchielo D and Bucher P and Carbonellcaballero J and Chaudhary K and Chinesta F and Chodavarapu P and Chow RD and Cokelaer T and Cubuk C and Dhanda SK and Dopazo J and Faux T and Feng Y and Flinta C and Guziolowski C and He D and Hidalgo MR and Hou J and Inoue K and Jaakkola MK and Ji J and Kumar R and Kumar S and Kursa MB and Li Q and Lopuszynski M and Lu P and Magnin M and Mao W and Miannay B and Nikolayeva I and Obradovic Z and Pak C and Rahman MM and Razzaq M and Ribeiro T and Roux O and Saghapour E and Saini H and Sarhadi S and Sato H and Schwikowski B and Sharma A and Sharma R and Singla D and Stojkovic I and Suomi T and Suprun M and Tian C and Tomalin LE and Xie L and Yu X and Pandey G and Chiu C and Mcclain MT and Woods CW and Ginsburg GS and Elo LL and Tsalik EL and Mangravite LM and Sieberts SK}, title = {A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection}, journal = {Nature Communications}, volume = {9}, number = {1}, pages = {-}, year = {2018} }

RIS

TY - JOUR
AU - Fourati S
AU - Talla A
AU - Mahmoudian M
AU - Burkhart JG
AU - Klen R
AU - Henao R
AU - Yu T
AU - Aydin Z
AU - Yeung KY
AU - Ahsen ME
AU - Almugbel R
AU - Jahandideh S
AU - Liang X
AU - Nordling TEM
AU - Shiga M
AU - Stanescu A
AU - Vogel R
AU - Abdallah EB
AU - Aghababazadeh FA
AU - Amadoz A
AU - Bhalla S
AU - Bleakley K
AU - Bongen E
AU - Borzacchielo D
AU - Bucher P
AU - Carbonellcaballero J
AU - Chaudhary K
AU - Chinesta F
AU - Chodavarapu P
AU - Chow RD
AU - Cokelaer T
AU - Cubuk C
AU - Dhanda SK
AU - Dopazo J
AU - Faux T
AU - Feng Y
AU - Flinta C
AU - Guziolowski C
AU - He D
AU - Hidalgo MR
AU - Hou J
AU - Inoue K
AU - Jaakkola MK
AU - Ji J
AU - Kumar R
AU - Kumar S
AU - Kursa MB
AU - Li Q
AU - Lopuszynski M
AU - Lu P
AU - Magnin M
AU - Mao W
AU - Miannay B
AU - Nikolayeva I
AU - Obradovic Z
AU - Pak C
AU - Rahman MM
AU - Razzaq M
AU - Ribeiro T
AU - Roux O
AU - Saghapour E
AU - Saini H
AU - Sarhadi S
AU - Sato H
AU - Schwikowski B
AU - Sharma A
AU - Sharma R
AU - Singla D
AU - Stojkovic I
AU - Suomi T
AU - Suprun M
AU - Tian C
AU - Tomalin LE
AU - Xie L
AU - Yu X
AU - Pandey G
AU - Chiu C
AU - Mcclain MT
AU - Woods CW
AU - Ginsburg GS
AU - Elo LL
AU - Tsalik EL
AU - Mangravite LM
AU - Sieberts SK
TI - A Crowdsourced Analysis to Identify Ab Initio Molecular Signatures Predictive of Susceptibility to Viral Infection
JO - Nature Communications
VL - 9
IS - 1
SP -
EP -
PY - 2018
ER -

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