Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Genome-Wide Association Study of Long Covid Publisher



Lammi V1 ; Nakanishi T1, 2, 3, 4, 5, 6 ; Jones SE1 ; Andrews SJ7 ; Karjalainen J1, 8, 9, 10 ; Cortes B11, 12 ; Obrien HE13 ; Ochoaguzman A14 ; Fultonhoward BE15 ; Broberg M1 ; Haapaniemi HH1 ; Kanai M16, 17 ; Pirinen M1, 18, 19 ; Schmidt A20 Show All Authors
Authors
  1. Lammi V1
  2. Nakanishi T1, 2, 3, 4, 5, 6
  3. Jones SE1
  4. Andrews SJ7
  5. Karjalainen J1, 8, 9, 10
  6. Cortes B11, 12
  7. Obrien HE13
  8. Ochoaguzman A14
  9. Fultonhoward BE15
  10. Broberg M1
  11. Haapaniemi HH1
  12. Kanai M16, 17
  13. Pirinen M1, 18, 19
  14. Schmidt A20
  15. Mitchell RE21, 22
  16. Mousas A23
  17. Mangino M24
  18. Huertachagoya A25, 26, 27, 28
  19. Sinnottarmstrong N29, 30, 31
  20. Cirulli ET32
  21. Vaudel M33, 34, 35
  22. Kwong ASF36
  23. Maiti AK37
  24. Marttila MM38, 39
  25. Posner DC40
  26. Rodriguez AA41
  27. Batini C42, 43
  28. Minnai F44, 45
  29. Dearman AR46
  30. Warmerdam CAR47, 48
  31. Sequeros CB49
  32. Winkler TW50
  33. Jordan DM51, 52
  34. Rescenko R53
  35. Miano L54
  36. Lane JM55, 56, 57
  37. Chung RK58
  38. Guillenguio B42, 59
  39. Leavy OC42, 59
  40. Carvajalsilva L60
  41. Aguilarvaldes K60
  42. Frangione E61
  43. Guare L62
  44. Vergasova E63
  45. Marouli E64
  46. Striano P65
  47. Zainulabid UA66
  48. Kumar A67
  49. Ahmad HF68
  50. Edahiro R69, 70
  51. Azekawa S71, 72
  52. Maj C127
  53. Pensel MC126
  54. Miller A20
  55. Nothen MM20
  56. Behzad P20
  57. Schultz S20
  58. Heggemann J20
  59. Balla D20
  60. Morrison DR121
  61. Mooser V120
  62. Perley D120
  63. Ragoussis J120
  64. Rousseau S125
  65. Shi F121
  66. Lathrop GM120
  67. Yanishevsky S120
  68. Laurent L121
  69. Auld D120
  70. Bertrand M124
  71. Boisclair A120
  72. Bourque G120
  73. Bujold D120
  74. Durand M122, 123
  75. Adra D121
  76. Stcyr J120
  77. Niemi MEK1, 18, 19
  78. Iyengar SK129, 130
  79. Cai T128
  80. Cho K73, 105
  81. Sarvadhavabhatla S91
  82. Donaire MS91
  83. Valenzuelajorquera H168
  84. Lamoza E60
  85. Arevalo TV60
  86. Retamalesortega R172
  87. Sanhueza S162
  88. Selman CS169
  89. Silva AX175, 176
  90. Alarcon TA169
  91. Martinez MF174
  92. Quiroga R162
  93. Zunigapacheco P158, 159
  94. Zapatacontreras D158, 159
  95. Yanez CE172
  96. Quinones LA173
  97. Tobarcalfucoy EA172
  98. Monardesramirez VA171
  99. Signore IA79, 170
  100. Guajardo LG169
  101. Figueroa A168
  102. Orostica KY167
  103. Munoz CA163
  104. Fuentesguajardo M166
  105. Bocchieri P79
  106. Cabrera C162
  107. Echeverria CA165
  108. Cerpa LC60
  109. Donoso G164
  110. Gutierrezrichards S163
  111. Novalamperti E162
  112. Saez Hidalgo JM161
  113. Espinosaparrilla Y158, 159, 160
  114. Hignell B46
  115. Forgetta V111
  116. Harvey NR157
  117. Erber J144
  118. Budde M139
  119. Heilbronner U139
  120. Larsson IM114
  121. Fricke L156
  122. Lipcsey M114
  123. Adorjan K154, 155
  124. Maricic T115
  125. Kalman JL139, 153
  126. Dinkel A152
  127. Mueller NS151
  128. Cordioli M1
  129. Protzer U108, 150
  130. Spinner CD144
  131. Senner F139
  132. Frithiof R114
  133. Wallin E114
  134. Winter C148, 149
  135. Schulze TG139, 145, 146, 147
  136. Schneider J144
  137. Wiltfang J141, 142, 143
  138. Papiol S139, 140
  139. Kripke CM138
  140. Verma A138
  141. Ritchie MD137
  142. Rader DJ136
  143. Trogstad L135
  144. Durangomez M14
  145. Pajukanta P132, 134
  146. Morenomacias H133
  147. Lee SHT132
  148. Aguilar Salinas CA131
  149. Castanovinyals G184, 185, 186
  150. Kogevinas M184, 185, 186, 187
  151. Farre X11, 12
  152. Carreras A181, 182, 183
  153. Dobano C179, 180
  154. Blay N11, 12
  155. Garciaaymerich J184, 185
  156. Blasco A181, 182, 183
  157. Moncunill G179, 180
  158. Iraolaguzman S11, 12
  159. De Cid R11, 12
  160. Guyatt AL42, 87
  161. Mortensen ASB178
  162. Feenstra B93
  163. Westergaard D49
  164. Brunak S49
  165. Ostrowski SR177
  166. Simons NW51, 52
  167. Sloofman LG51, 52
  168. Charney AW51, 204
  169. Thompson RC51, 52
  170. Namkoong H203
  171. Amirsavadkouhi A202
  172. Tadi HA201
  173. Sharififard B100
  174. Soltani N201
  175. Zarei V200
  176. Aliannejad R199
  177. Ntzani E23, 198
  178. Evangelou E23, 99
  179. Liontos A196
  180. Tzoulaki I197
  181. Milionis H196
  182. Christaki E196
  183. Schiabor Barrett KM32
  184. Bolze A32
  185. Dabe S195
  186. Neveux I194
  187. White S32
  188. Washington NL32
  189. Sandoval E32
  190. Tanudjaja F32
  191. Kamelin A63
  192. Ilinsky V193
  193. Kharitonov D63
  194. Kim A63
  195. Plotnikov N63
  196. Shaheen L63
  197. Trofimov M63
  198. Ilinskaya A193
  199. Hannah T13
  200. Colombo F192
  201. Baldassarri M96, 97, 98
  202. Zguro K191
  203. Fallerini C189, 190
  204. Furini S188
  205. Maher M117, 118, 119
  206. Cherry JM55
  207. Burns AC206
  208. Saxena R117, 118, 119
  209. Klovins J53
  210. Briviba M53
  211. Raitis P53
  212. Rovite V53
  213. Elliott LT205
  214. Taher J61, 77
  215. Xinyi X61
  216. Vishnyakova O205
  217. Karlsen TH94
  218. Blasi FBA54, 208
  219. Blandini F208
  220. Bandera A54, 208
  221. Degenhardt F209
  222. Nobili A207
  223. Montano N54
  224. Iannotti N208
  225. Ellinghaus D209
  226. Franke A209
  227. Mantero M208
  228. Lamorte G208
  229. Malvestiti F54
  230. Margarita S208
  231. Muscatello A208
  232. Carpani R208
  233. Peyvandi F54, 208
  234. Prati D208
  235. Ronzoni L208
  236. Tettamanti M207
  237. Kukkonen A101
  238. Luoh SW73, 74
  239. Erikstrup C75
  240. Pedersen OBV76
  241. Lernerellis J61, 77, 78
  242. Colombo A60, 79, 80
  243. Grzymski JJ81
  244. Ishii M71, 72
  245. Okada Y5, 69, 82, 83
  246. Beckmann ND51, 84
  247. Kumari M46
  248. Wagner R85, 86
  249. Heid IM50
  250. John C42, 87
  251. Short PJ13
  252. Magnus P88
  253. Ansone L53
  254. Valenti LVC89, 90
  255. Lee SA91
  256. Wain LV42, 59
  257. Verdugo RA60, 92
  258. Banasik K49
  259. Geller F93
  260. Franke LH47, 48
  261. Rakitko A63
  262. Duncan EL94, 95
  263. Renieri A96, 97, 98
  264. Tsilidis KK23, 99
  265. De Cid R11, 12
  266. Niavarani A100
  267. Abner E101
  268. Tusieluna T102, 103
  269. Verma SS62
  270. Smith GD21, 22
  271. Timpson NJ21, 22
  272. Madduri RK104
  273. Daly MJ1, 16, 17
  274. Ganna A1, 16, 17
  275. Schulte EC106, 107, 108, 109, 110
  276. Richards JB2, 3, 24, 111, 112
  277. Ludwig KU20
  278. Markshultstrom M112, 113, 114
  279. Zeberg H115, 116
  280. Ollila HM1, 117, 118, 119

Source: Nature Genetics Published:2025


Abstract

Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association of FOXP4 with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4’s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID. © The Author(s) 2025.
Other Related Docs
4. Sars-Cov-2 in Brief: From Virus to Prevention, Osong Public Health and Research Perspectives (2022)
11. Ten Challenging Questions About Sars-Cov-2 and Covid-19, Expert Review of Respiratory Medicine (2020)
14. Coronavirus: Pure Infectious Disease or Genetic Predisposition, Advances in Experimental Medicine and Biology (2021)
16. Host Factors: Implications in Immunopathogenesis of Covid-19, Pathology Research and Practice (2021)