Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Neuroprotective Effects of Paeoniflorin in Neurodegenerative Diseases of the Central Nervous System Publisher



Manayi A1 ; Omidpanah S1 ; Barreca D2 ; Ficarra S2 ; Daglia M3 ; Nabavi SF4 ; Nabavi SM4
Authors

Source: Phytochemistry Reviews Published:2017


Abstract

Paeoniflorin is a monoterpene glycoside, the β-glucoside of paeoniflorigenin. It is one of the major components of Radix Paeoniae, the herbal product obtained from Paeonia lactiflora Pall., a medicinal plant used in folk medicine, especially in Chinese Traditional Medicine, to treat several human ailments, including dementia and cognitive decline. The neuroprotective effects of paeoniflorin have been studied by many investigations showing that its beneficial effects may derive from its anti-inflammatory and anti-apoptotic properties, and its ability to promote neuronal survival. This review evaluates scientific evidence on the neuroprotective properties of paeoniflorin. On the basis of literature data, paeoniflorin seems to be a promising compound for the prevention and treatment of neurodegenerative disorders, though definitive recommendation requires further studies. © 2017, Springer Science+Business Media B.V.
Related Docs
View other Related Docs
1. Phytochemicals As Future Drugs for Parkinson's Disease: A Comprehensive Review, Reviews in the Neurosciences (2016)
2. Apigenin As Neuroprotective Agent: Of Mice and Men, Pharmacological Research (2018)
3. Pistacia Genus As a Potential Source of Neuroprotective Natural Products, Planta Medica (2019)
Experts (# of related papers)
View all Related Experts
Ahmad Reza Dehpour (3)
Roja Rahimi (2)
Other Related Docs
4. Neuroprotective Effects of Chrysin: From Chemistry to Medicine, Neurochemistry International (2015)
5. Protective Effects of Flavonoids Against Alzheimer's Disease-Related Neural Dysfunctions, Biomedicine and Pharmacotherapy (2017)
6. Naturally Occurring Chemicals Against Alzheimer’S Disease, Naturally Occurring Chemicals against Alzheimer’s Disease (2020)
7. Neuroinflammation As a Potential Therapeutic Target in Neuroimmunological Diseases, Translational Neuroimmunology: Neuroinflammation: Volume 7 (2023)
8. The Use of Natural Products for Preventing Cognitive Decline/Providing Neuroprotection, Handbook of Experimental Pharmacology (2025)
9. Medicinal Plants in Neurodegenerative Diseases: Perspective of Traditional Persian Medicine, Current Drug Metabolism (2018)
10. Dementia Etiologies and Remedies in Traditional Persian Medicine; a Review of Medicinal Plants and Phytochemistry, Current Drug Metabolism (2018)
11. Neuroprotective Effects of Fisetin in Alzheimer’S and Parkinson’S Diseases: From Chemistry to Medicine, Current Topics in Medicinal Chemistry (2016)
12. Fasudil Attenuates Lipopolysaccharide-Induced Cognitive Impairment in C57bl/6 Mice Through Anti-Oxidative and Anti-Inflammatory Effects: Possible Role of Aquaporin-4, IBRO Neuroscience Reports (2024)
13. The Flavone Luteolin Improves Central Nervous System Disorders by Different Mechanisms: A Review, Journal of Molecular Neuroscience (2018)
14. Quercetin Attenuates Depressive-Like Behavior in a Rat Model of Alzheimer’S Disease: Involvement of Galectin-3 Signaling Pathway, Research Journal of Pharmacognosy (2024)
15. Atorvastatin Prevents the Neuron Loss in the Hippocampal Dentate Gyrus Region Through Its Anti-Oxidant and Anti-Apoptotic Activities, CNS and Neurological Disorders - Drug Targets (2021)
16. Berberine and Neurodegeneration: A Review of Literature, Pharmacological Reports (2015)
17. The Neuroprotective Mechanisms of Kaempferol in Experimental Ischemic Stroke: A Preclinical Systematic Review, Molecular Neurobiology (2025)
18. The Beneficial Effects of Hmg-Coa Reductase Inhibitors in the Processes of Neurodegeneration, Metabolic Brain Disease (2017)
19. Effects of Thymol on Amyloid-Β-Induced Impairments in Hippocampal Synaptic Plasticity in Rats Fed a High-Fat Diet, Brain Research Bulletin (2018)
20. Nanoformulated Herbal Bioactives for the Treatment of Neurodegenerative Disorders, Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities (2022)