Nanoformulated Herbal Bioactives for the Treatment of Neurodegenerative Disorders Publisher



Sajadimajd S¹ ; Moradi SZ^{2, 3} ; Akbari V^{1, 4} ; Aghaz F⁵ ; Farzaei MH^{6, 7}
Source: Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities Published:2022

Abstract

Neurodegenerative diseases (NDs) refer to a number of chronic progressive neurological disorders due to degradation and dysfunction of neurons. A great promise for the prevention of many NDs, herbal bioactives offer better opportunities than synthetic medical agents. However, given the low solubility and bioavailability, nanoformulation enables controlled release and therapeutic effects of natural products. In this line, the objective of this study is to evaluate the therapeutic effects of natural products and their nanostructures in several types of neurodegenerative in vitro and in vivo models. The neuroprotective potential of a number of plants and their constituents from Ayurveda, Iranian, South American, African, and Chinese medicine has been reported in NDs. Owing to the low blood-brain penetration of natural products, the effectiveness of nanoformulated forms was evaluated in NDs. The cumulative of these observations reveals that nanotechnology-based natural products hold great promise for management and treatment of NDs. © 2022 Elsevier Inc. All rights reserved.