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Cd147 and Cyclophilin A: A Promising Potential Targeted Therapy for Covid-19 and Associated Cancer Progression and Chemo-Resistance Publisher



Bakhtiyari M1, 2 ; Haji Aghasi A3 ; Banihashemi S4 ; Abbassioun A5 ; Tavakol C6 ; Zalpoor H2, 7
Authors

Source: Infectious Agents and Cancer Published:2023


Abstract

Coronavirus disease-2019 (COVID-19), as a worldwide serious issue has been shown to lead to progression and poor outcomes in cancer patients. The underlying mechanisms for SARS-CoV-2 infection’s adverse effects on cancer patients have not been fully understood. We hypothesized that CD147 and Cyclophilin A (CyPA) not only can play a significant role in infection severity but also can contribute to cancer progression and chemotherapy resistance in cancer patients with COVID-19. In addition, we hypothesized that the expression of both CD147 and CyPA could be increased by Hypoxia-inducible Factor-1 alpha (HIF-1α) activation during hypoxic conditions that occurred during COVID-19. Therefore, this evidence can open a new window in the management of cancer patients during the pandemic and therapeutic approaches targeting CD147 and CyPA could be a potentially promising therapeutic approach for such patients. © 2023, The Author(s).
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