Emerging Role of Mesenchymal Stromal Cells (Mscs)-Derived Exosome in Neurodegeneration-Associated Conditions: A Groundbreaking Cell-Free Approach

Emerging Role of Mesenchymal Stromal Cells (Mscs)-Derived Exosome in Neurodegeneration-Associated Conditions: A Groundbreaking Cell-Free Approach Publisher Pubmed

Yari H¹ ; Mikhailova MV² ; Mardasi M³ ; Jafarzadehgharehziaaddin M⁴ ; Shahrokh S⁵ ; Thangavelu L⁶ ; Ahmadi H⁷ ; Shomali N⁸ ; Yaghoubi Y⁹ ; Zamani M¹⁰ ; Akbari M⁸ ; Alesaeidi S¹¹

Source: Stem Cell Research and Therapy Published:2022

Abstract

Accumulating proofs signify that pleiotropic effects of mesenchymal stromal cells (MSCs) are not allied to their differentiation competencies but rather are mediated mainly by the releases of soluble paracrine mediators, making them a reasonable therapeutic option to enable damaged tissue repair. Due to their unique immunomodulatory and regenerative attributes, the MSC-derived exosomes hold great potential to treat neurodegeneration-associated neurological diseases. Exosome treatment circumvents drawbacks regarding the direct administration of MSCs, such as tumor formation or reduced infiltration and migration to brain tissue. Noteworthy, MSCs-derived exosomes can cross the blood–brain barrier (BBB) and then efficiently deliver their cargo (e.g., protein, miRNAs, lipid, and mRNA) to damaged brain tissue. These biomolecules influence various biological processes (e.g., survival, proliferation, migration, etc.) in neurons, oligodendrocytes, and astrocytes. Various studies have shown that the systemic or local administration of MSCs-derived exosome could lead to the favored outcome in animals with neurodegeneration-associated disease mainly by supporting BBB integrity, eliciting pro-angiogenic effects, attenuating neuroinflammation, and promoting neurogenesis in vivo. In the present review, we will deliver an overview of the therapeutic benefits of MSCs-derived exosome therapy to ameliorate the pathological symptoms of acute and chronic neurodegenerative disease. Also, the underlying mechanism behind these favored effects has been elucidated. © 2022, The Author(s).

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Gholamreza Hassanzadeh (2)

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Style	Citing Format
MLA	Yari H, et al.. "Emerging Role of Mesenchymal Stromal Cells (Mscs)-Derived Exosome in Neurodegeneration-Associated Conditions: A Groundbreaking Cell-Free Approach." Stem Cell Research and Therapy, vol. 13, no. 1, 2022, pp. -.
APA	Yari H, Mikhailova MV, Mardasi M, Jafarzadehgharehziaaddin M, Shahrokh S, Thangavelu L, Ahmadi H, Shomali N, Yaghoubi Y, Zamani M, Akbari M, Alesaeidi S (2022). Emerging Role of Mesenchymal Stromal Cells (Mscs)-Derived Exosome in Neurodegeneration-Associated Conditions: A Groundbreaking Cell-Free Approach. Stem Cell Research and Therapy, 13(1), -.
Chicago	Yari H, Mikhailova MV, Mardasi M, Jafarzadehgharehziaaddin M, Shahrokh S, Thangavelu L, Ahmadi H, et al.. "Emerging Role of Mesenchymal Stromal Cells (Mscs)-Derived Exosome in Neurodegeneration-Associated Conditions: A Groundbreaking Cell-Free Approach." Stem Cell Research and Therapy 13, no. 1 (2022): -.
Harvard	Yari H et al. (2022) 'Emerging Role of Mesenchymal Stromal Cells (Mscs)-Derived Exosome in Neurodegeneration-Associated Conditions: A Groundbreaking Cell-Free Approach', Stem Cell Research and Therapy, 13(1), pp. -.
Vancouver	Yari H, Mikhailova MV, Mardasi M, Jafarzadehgharehziaaddin M, Shahrokh S, Thangavelu L, et al.. Emerging Role of Mesenchymal Stromal Cells (Mscs)-Derived Exosome in Neurodegeneration-Associated Conditions: A Groundbreaking Cell-Free Approach. Stem Cell Research and Therapy. 2022;13(1):-.
BibTex	@article{ author = {Yari H and Mikhailova MV and Mardasi M and Jafarzadehgharehziaaddin M and Shahrokh S and Thangavelu L and Ahmadi H and Shomali N and Yaghoubi Y and Zamani M and Akbari M and Alesaeidi S}, title = {Emerging Role of Mesenchymal Stromal Cells (Mscs)-Derived Exosome in Neurodegeneration-Associated Conditions: A Groundbreaking Cell-Free Approach}, journal = {Stem Cell Research and Therapy}, volume = {13}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Yari H AU - Mikhailova MV AU - Mardasi M AU - Jafarzadehgharehziaaddin M AU - Shahrokh S AU - Thangavelu L AU - Ahmadi H AU - Shomali N AU - Yaghoubi Y AU - Zamani M AU - Akbari M AU - Alesaeidi S TI - Emerging Role of Mesenchymal Stromal Cells (Mscs)-Derived Exosome in Neurodegeneration-Associated Conditions: A Groundbreaking Cell-Free Approach JO - Stem Cell Research and Therapy VL - 13 IS - 1 SP - EP - PY - 2022 ER -

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