Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Mesenchymal Stem Cell Exosomes: A Two-Edged Sword in Cancer Therapy Publisher Pubmed



Vakhshiteh F1 ; Atyabi F1, 2 ; Ostad SN3
Authors

Source: International Journal of Nanomedicine Published:2019


Abstract

Mesenchymal stem cells (MSCs) are multipotent stromal cells present in various adult tissues. Several studies suggest that MSCs secrete exosomes that perform as mediators in the tumor niche and play several roles in tumorigenesis, angiogenesis, and metastasis. In contrast, there are other studies supporting the tumor-suppressing effects of MSC-derived exosomes. Therefore, the exact association of MSC exosomes and tumor cells remains open to debate. This review aimed to demonstrate the present knowledge of MSC-derived exosomes in cancer research and to illustrate current approaches to make use of modified exosomes as a platform in therapeutic strategies in cancer. © 2019 Vakhshiteh et al.
Related Docs
View other Related Docs
1. Mesenchymal Stem/Stromal Cell-Derived Exosomes in Regenerative Medicine and Cancer; Overview of Development, Challenges, and Opportunities, Stem Cell Research and Therapy (2021)
2. Exosomal Micrornas Derived From Mesenchymal Stem Cells: Cell-To-Cell Messages, Cell Communication and Signaling (2020)
3. Diagnostic and Therapeutic Potential of Exosomes in Cancer: The Beginning of a New Tale?, Journal of Cellular Physiology (2017)
Experts (# of related papers)
View all Related Experts
Hamid Reza Mirzaei (2)
Mohammad Vasei (1)
Other Related Docs
4. The Extracellular Vesicles-Derived From Mesenchymal Stromal Cells: A New Therapeutic Option in Regenerative Medicine, Journal of Cellular Biochemistry (2018)
5. Effect of Mesenchymal Stem Cells-Derived Exosomes on Tumor Microenvironment: Tumor Progression Versus Tumor Suppression, Journal of Cellular Physiology (2019)
6. Designer Exosomes: A New Platform for Biotechnology Therapeutics, BioDrugs (2020)
7. The Relationship Between Molecular Content of Mesenchymal Stem Cells Derived Exosomes and Their Potentials: Opening the Way for Exosomes Based Therapeutics, Biochimie (2019)
8. Recent Advancements to Engineer Mesenchymal Stem Cells and Their Extracellular Vesicles for Targeting and Destroying Tumors, Progress in Biophysics and Molecular Biology (2023)
9. Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications, Current Medicinal Chemistry (2021)
10. Exosome Engineering in Cell Therapy and Drug Delivery, Inflammopharmacology (2023)
11. Prospects for Manipulation of Mesenchymal Stem Cells in Tumor Therapy: Anti-Angiogenesis Property on the Spotlight, International Journal of Stem Cells (2021)
12. The Potential Use of Mesenchymal Stem Cells-Derived Exosomes As Micrornas Delivery Systems in Different Diseases, Cell Communication and Signaling (2023)
13. Texosome-Based Drug Delivery System for Cancer Therapy: From Past to Present, Cancer Biology and Medicine (2015)
14. Improvement, Scaling-Up, and Downstream Analysis of Exosome Production, Critical Reviews in Biotechnology (2020)
15. Current Knowledge on Therapeutic, Diagnostic, and Prognostics Applications of Exosomes in Multiple Myeloma: Opportunities and Challenges, Archives of Biochemistry and Biophysics (2024)
16. Exosomes As a Next-Generation Drug Delivery System: An Update on Drug Loading Approaches, Characterization, and Clinical Application Challenges, Acta Biomaterialia (2020)
17. The Therapeutic Potential of Mesenchymal Stem Cell–Derived Exosomes in Treatment of Neurodegenerative Diseases, Molecular Neurobiology (2019)
18. Exosomes Derived From Mir-34A-Overexpressing Mesenchymal Stem Cells Inhibit in Vitro Tumor Growth: A New Approach for Drug Delivery, Life Sciences (2021)
19. Therapeutic Role of Mesenchymal Stem Cell-Derived Exosomes in Respiratory Disease, Stem Cell Research and Therapy (2022)
20. Extracellular Vesicles Biogenesis, Isolation, Manipulation and Genetic Engineering for Potential in Vitro and in Vivo Therapeutics: An Overview, Frontiers in Bioengineering and Biotechnology (2022)