The Pathological Characteristics of Cervical Conization and Cervical Intraepithelial Cancer Recurrence Rate Based on Different Age Groups Publisher



Ghahghaeinezamabadi A¹ ; Tehranian A¹ ; Akhavan S² ; Rezayof E³ ; Tajik N¹
Source: Journal of Obstetrics, Gynecology and Cancer Research Published:2024

Abstract

Background & Objective: Immunosuppression, HPV persistence, and smoking are the main-related risk factors of Cervical Intraepithelial Neoplasia (CIN) recurrence. However, age as a basic factor may be a main factor related to CIN recurrence. Therefore, our study aimed to detect the potential role of women's age in CIN recurrence. Materials & Methods: This cross-sectional study was conducted on 329 patients who underwent conization in the gynecology-oncology clinics of Arash and Imam Khomeini hospitals affiliated with Tehran University of Medical Sciences between March 2016 and March 2021. Results: Totally, 329 cases were enrolled in the study. Most women were in their thirties. CIN recurrence was about 10.0% (32 cases). The CIN recurrence rate was 8.9% in women younger than 30, 10.2% in 30-40, 11.3% in 40-50, and 5.6% in 50–60 decades. There was no significant (p-value=0.802) difference in recurrence rate among age groups. There was a significant (p-value=0.023) difference in the frequency of endocervical involvement regarding age category, women aged 40 to 50 had the most frequent marginal involvement with 26.8%, while there was no significant (p-value=0.802) difference in frequency of marginal involvement regards age category. Conclusion: CIN cases with age higher than 40 years need to have more caution and tight follow-up visit after conization. © 2024, Farname Inc. All rights reserved.