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The Prevalence of Hpv and Non-Hpv Stis Among Iranian Women and Assessment of the Hpv/Non-Hpv Stis Co-Infection on Cervical Cell Changes Publisher



Pouryasin M1 ; Mousavi AS2, 3, 4 ; Pakravesh J5 ; Kamel DZ1 ; Nooriardabili S6 ; Khodadad S3, 7 ; Aminimoghaddam S8 ; Ghazimoghadam M9 ; Farbod Y8 ; Pouryasin A1
Authors

Source: Journal of Obstetrics# Gynecology and Cancer Research Published:2022


Abstract

Background & Objective: Persistent infection with some types of Human papillomavirus (HPV), which are high-risk genotypes, can lead the patients toward cervical cancer and, finally, death. Recent studies showed HPV co-infection with non-HPV sexually transmitted infections (non-HPV STIs) could increase the persistency rate of HPV infections. This study aimed to estimate the prevalence of STIs and assess the association of HPV/non-HPV STIs co-infection on cervical cell changes based on cytological findings. Materials & Methods: In this cross-sectional study, in addition to the routine cervical screening, including HPV testing and cytological assessment, non-HPV STI testing was performed on 1065 Iranian women. To assess the HPV and non-HPV STIs, commercial kits were used. Results: 964 (90.5%) women had normal cytology (NILM) results. The overall prevalence of HPV and non-HPV STIs were 39.1% and 68.5%, respectively. HPV-53 (6.5%),-16 (6.1%) and-31 (5.5%) were found as the most prevalent genotypes. Ureaplasma Parvum (UP) (42.7%), Group B Streptococcus (GBS) (23.7%), Candida Species (CS) (23.6%), Ureaplasma Urealyticum (UU) (9.6%), and Mycoplasma Hominis (MH) (7.1%) were found as the most prevalent non-HPV STIs. The co-infection of HPV with GBS played an important role in developing the cervical lesion (P<0.05). Conclusion: In the present study, the STIs, including HPV, UP, GBS, CS, UU, and MH, were prevalent among the study participant, and it was found that the HPV/GBS co-infection played a significant role in the development of LSIL or worse cytological grades. To clarify this issue, further studies will be conducted. © 2022, Farname Inc. All rights reserved.
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