Solvent-Free Synthesis of Novel Benzodiazepine Derivatives by a Three-Component Base-Catalysed Reaction of Isatoic Anhydride, a Primary Amine and Chloroacetyl Chloride

Solvent-Free Synthesis of Novel Benzodiazepine Derivatives by a Three-Component Base-Catalysed Reaction of Isatoic Anhydride, a Primary Amine and Chloroacetyl Chloride Publisher

Seydey MK¹ ; Rezaei Z² ; Homami SS¹

Source: Journal of Chemical Research Published:2015

Abstract

Heating isatoic anhydride with a series of primary amines at 150 °C under solvent-free conditions yielded 2-amino-N-alkylbenzamides which, in the same pot, reacted readily with chloroacetyl chloride in the presence of poly(dimethylaminoethyl acrylamide)-modified magnetic nanoparticles (MNP@PDMA), a base catalyst, to give 4-alkyl-1,4-benzodiazepine-2,5-diones in good yields without formation of by-products.

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Mohammad Mahdavi (6)

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Style	Citing Format
MLA	Seydey MK, Rezaei Z, Homami SS. "Solvent-Free Synthesis of Novel Benzodiazepine Derivatives by a Three-Component Base-Catalysed Reaction of Isatoic Anhydride, a Primary Amine and Chloroacetyl Chloride." Journal of Chemical Research, vol. 39, no. 5, 2015, pp. 286-288.
APA	Seydey MK, Rezaei Z, Homami SS (2015). Solvent-Free Synthesis of Novel Benzodiazepine Derivatives by a Three-Component Base-Catalysed Reaction of Isatoic Anhydride, a Primary Amine and Chloroacetyl Chloride. Journal of Chemical Research, 39(5), 286-288.
Chicago	Seydey MK, Rezaei Z, Homami SS. "Solvent-Free Synthesis of Novel Benzodiazepine Derivatives by a Three-Component Base-Catalysed Reaction of Isatoic Anhydride, a Primary Amine and Chloroacetyl Chloride." Journal of Chemical Research 39, no. 5 (2015): 286-288.
Harvard	Seydey MK, Rezaei Z, Homami SS (2015) 'Solvent-Free Synthesis of Novel Benzodiazepine Derivatives by a Three-Component Base-Catalysed Reaction of Isatoic Anhydride, a Primary Amine and Chloroacetyl Chloride', Journal of Chemical Research, 39(5), pp. 286-288.
Vancouver	Seydey MK, Rezaei Z, Homami SS. Solvent-Free Synthesis of Novel Benzodiazepine Derivatives by a Three-Component Base-Catalysed Reaction of Isatoic Anhydride, a Primary Amine and Chloroacetyl Chloride. Journal of Chemical Research. 2015;39(5):286-288.
BibTex	@article{ author = {Seydey MK and Rezaei Z and Homami SS}, title = {Solvent-Free Synthesis of Novel Benzodiazepine Derivatives by a Three-Component Base-Catalysed Reaction of Isatoic Anhydride, a Primary Amine and Chloroacetyl Chloride}, journal = {Journal of Chemical Research}, volume = {39}, number = {5}, pages = {286-288}, year = {2015} }
RIS	TY - JOUR AU - Seydey MK AU - Rezaei Z AU - Homami SS TI - Solvent-Free Synthesis of Novel Benzodiazepine Derivatives by a Three-Component Base-Catalysed Reaction of Isatoic Anhydride, a Primary Amine and Chloroacetyl Chloride JO - Journal of Chemical Research VL - 39 IS - 5 SP - 286 EP - 288 PY - 2015 ER -

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