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Anticonvulsant Effects of New 1, 4-Dihydropyridinederivatives Containing Imidazolyl Moiety Against Seizures Induced by Pentylenetetrazole and Maximal Electroshock in Mice



Rasouli Y1 ; Davood A1 ; Alaee A2 ; Dehqani G1 ; Shafaroudi H2 ; Lotfinia M1 ; Amini M3 ; Shafiee A3
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Source: Iranian Journal of Pharmaceutical Research Published:2017

Abstract

Epilepsy is a chronic disorder of the brain affecting around 50 million people in the world. Up to 30% of epileptic patients do not respond to available drugs and medical therapies. In this paper, anticonvulsant screening of 10 synthesized new derivatives of 1, 4-dihydropyridine-3, 5-dicarboxamides was performed. Anticonvulsant activity was evaluated by intravenous and intraperitoneal pentylenetetrazole and maximal electroshock induced seizures tests. Nifedipine was used as reference drug. Our pharmacological results revealing the compounds 2, 4, 5, and 6 can be effective in both absence and grandmal seizures in human. These pharmacological studies have displayed that these new dihydropyridine derivatives are capable to inhibiting seizures induced by pentylenetetrazole and maximal electroshock in mice efficiently. © 2017 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services.
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