Tehran University of Medical Sciences

Science Communicator Platform

Share By
Emerging Role of Long Non-Coding Rnas in the Pathogenesis of Periodontitis Publisher Pubmed



Sayad A1 ; Mirzajani S1, 2 ; Gholami L3 ; Razzaghi P4 ; Ghafourifard S5 ; Taheri M6
Authors

Source: Biomedicine and Pharmacotherapy Published:2020


Abstract

Periodontitis is a bacteria-related chronic immune-associated condition that destructs bone and connective tissues around teeth. With a high incidence rate, it is regarded as a condition that impose substantial health burden. About half of the variance in the severity of periodontitis is attributed to genetic factors. Long non-coding RNAs (lncRNAs) have crucial roles in the development of several disorders such as periodontitis. A number of studies have reported dysregulation of lncRNAs such as UCA1, ANRIL, FGD5-AS1, NEAT1, FAS-AS1, Linc-RAM and NKILA in gingival tissues or blood samples of patients with periodontitis in comparison with healthy subjects. Moreover, several single nucleotide polymorphisms within lncRNAs have been associated with the susceptibility to this disorder. In the current review, we discuss the most recent articles about the role of lncRNAs in the pathogenesis of periodontitis. © 2020
Related Docs
View other Related Docs
1. The Lncrna Anril Is Down-Regulated in Peripheral Blood of Patients With Periodontitis: Long Non-Coding Rna and Periodontitis, Non-coding RNA Research (2020)
2. Dysregulation of Lncrnas in Circulation of Patients With Periodontitis: Results of a Pilot Study, BMC Oral Health (2021)
3. Exploring the Role of Long Non-Coding Rnas in Periodontitis, Meta Gene (2020)
Experts (# of related papers)
View all Related Experts
Abbas Bahador (1)
Mohammad Ali Sahraian (1)
Other Related Docs
4. Genetic Susceptibility for Periodontitis With Special Focus on Immune-Related Genes: A Concise Review, Gene Reports (2020)
5. Expression Analysis of Wnt Signaling Pathway Related Lncrnas in Periodontitis: A Pilot Case-Control Study, Human Gene (2022)
6. Assessment of Expression of a Number of Immune-Related Genes in the Periodontitis, Ecological Genetics and Genomics (2022)
7. Expression of Apoptosome-Related Genes in Periodontitis, Gene Reports (2021)
8. Altered Expression of Stat Genes in Periodontitis, Human Antibodies (2021)
9. Effects of Micro Rnas and Their Targets in Periodontal Diseases, Infectious Disorders - Drug Targets (2018)
10. Long Non-Coding Rna Signatures in Lymphopoiesis and Lymphoid Malignancies, Non-coding RNA (2023)
11. The Investigation of Apoptosis-Related Genes in Periodontitis, BMC Research Notes (2025)
12. The Salivary Exosomal Microrna As a Potential Biomarker in Patients With Periodontitis and Oral Cancers, Chemical Biology and Drug Design (2023)
13. Hotair But Not Anril Long Non-Coding Rna Contributes to the Pathogenesis of Multiple Sclerosis, Immunology (2018)
14. The Homeostasis and Therapeutic Applications of Innate and Adaptive Immune Cells in Periodontitis, Oral Diseases (2023)
15. Micrornas Function in Dental Stem Cells As a Promising Biomarker and Therapeutic Target for Dental Diseases, Molecular Diagnosis and Therapy (2023)
16. Decoding Noncoding Rnas: Mastering Bone Morphogenetic Protein Signaling and Crosstalk Pathways for Breakthroughs in Periodontal Regeneration, DNA and Cell Biology (2025)
17. Novel Insights Into the Interaction Between Long Non-Coding Rnas and Micrornas in Glioma, Molecular and Cellular Biochemistry (2021)
18. Epigenetic Changes Underlie the Association Between Diabetes Mellitus and Oral Diseases, Molecular Biology Reports (2023)
19. Long Noncoding Rnas and Exosomal Lncrnas: Classification, and Mechanisms in Breast Cancer Metastasis and Drug Resistance, Oncogene (2020)
20. Effect of Periodontal Treatment on the Crevicular Level of High-Mobility Group Box 1 and Soluble Triggering Receptor Expressed on Myeloid Cells 1 in Patients With Chronic Periodontitis, Iranian Journal of Allergy# Asthma and Immunology (2017)