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Genetic Susceptibility for Periodontitis With Special Focus on Immune-Related Genes: A Concise Review Publisher



Sayad A1, 2 ; Gholami L3 ; Mirzajani S2, 4 ; Omrani MD2 ; Ghafourifard S1 ; Taheri M5
Authors

Source: Gene Reports Published:2020


Abstract

Periodontal disease (PD) is complex multifactorial disorder with high burden for health system. This disorder is caused by interaction of several genetic and environmental factors. About one third of the observed variance in the frequency of this condition is due to the genetic factors. Several genetic loci particularly in cytokine coding genes have been associated with risk of this disorder. CD14, IL-6, TNF-α, IL-10, IL-1 α and IL-1β have been among the mostly assessed genes in this regard. However, there is no consensus on association between a certain SNP and PD in different populations. In addition to these genes, GLT6D1, TENM2 and LDLRAD4 have been identified to be associated with PD through genome wide association studies. In the current review, we summarize the most important data about the role of genetic factors in PD. © 2020 Elsevier Inc.
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