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Obesity and Diabetic Complications: A Study From the Nationwide Diabetes Report of the National Program for Prevention and Control of Diabetes (Nppcd-2021) Implications for Action on Multiple Scales Publisher Pubmed



Moosaie F1 ; Ghaemi F2 ; Mechanick JI3 ; Shadnoush M4 ; Firouzabadi FD1 ; Kermanchi J5 ; Poopak A1 ; Esteghamati S1 ; Forouzanfar R6 ; Abhari SMF7 ; Mansournia MA8 ; Khosravi A9 ; Gholami E1 ; Nakhjavani M1 Show All Authors
Authors
  1. Moosaie F1
  2. Ghaemi F2
  3. Mechanick JI3
  4. Shadnoush M4
  5. Firouzabadi FD1
  6. Kermanchi J5
  7. Poopak A1
  8. Esteghamati S1
  9. Forouzanfar R6
  10. Abhari SMF7
  11. Mansournia MA8
  12. Khosravi A9
  13. Gholami E1
  14. Nakhjavani M1
  15. Esteghamati A1

Source: Primary Care Diabetes Published:2022


Abstract

Background: Obesity plays a major role in the pathogenesis and development of macro- and microvascular complications of type 2 diabetes (T2D) and type 1 diabetes (T1D). We aimed to assess the association between obesity and macrovascular and microvascular complications of diabetes. Methods: This study consisted of 111,830 patients (age range: 1–106) with diabetes including 10,641 T1D (3187 obese [38.2% men] and 7454 non-obese [45.5% men]) and 101,189 T2D (51,873 obese [27.5% men] and 49,316 non-obese [33.4% men]) from the National Program for Prevention and Control of Diabetes (NPPCD-2021) in Iran, who attended academic tertiary care outpatient clinics from February 2016 to April 2021. A pooled logistic regression model was used to examine the association between obesity and diabetic complications. Results: Among patients with T1D, a significant association was found between obesity and cardiovascular disease (CVD), neuropathy, nephropathy and retinopathy (OR= 1.75, 1.56, 1.80 and 1.92, P-value= 0.001, 0.004, 0.001 and <0.001, respectively). In T2D, a statistically significant association was found between obesity and CVD, neuropathy and nephropathy (OR= 1.63, 1.98, 1.21, respectively, P-values <0.001). Conclusion: Obesity was independently associated with CVD, neuropathy and nephropathy in patients with T1D and T2D and with retinopathy only in T1D, to different degrees. The association between obesity and retinopathy and neuropathy was the strongest among T1D and T2D, respectively. Findings from this study suggest that obesity affects diabetic complications differently among the two types of diabetes, in terms of epidemiology and pathophysiology. This signifies the importance of different preventive and therapeutic approaches to obesity in T1D compared to T2D, on a national and global scale. © 2022 Primary Care Diabetes Europe
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