Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Altered Ifn-Γ Levels After Treatment of Epileptic Patients With Omega-3 Fatty Acids Publisher Pubmed



Ghafourifard S1 ; Hashemi M2 ; Rafigh M3 ; Omrani MA4 ; Hussen BM5 ; Sayad A6 ; Taheri M7
Authors

Source: Journal of Molecular Neuroscience Published:2021


Abstract

Epilepsy is a frequent chronic disorder of the brain characterized by intermittent epileptic seizures caused by hypersynchronous discharge of neurons in the brain. Studies have reported the role of cytokines in the pathogenesis of epilepsy, and a number of investigations have shown decreased levels of omega-3 fatty acids in epileptic patients. We investigated differences in serum levels of two cytokines, transforming growth factor (TGF)-β and interferon (IFN)-γ, in 40 epileptic cases prior to and after treatment with omega-3 fatty acids. IFN-γ levels were significantly increased after the 16-week treatment period (P < 0.001). However, TGF-β levels remained unchanged (P = 0.14). Omega-3 fatty acid treatment may alter the immune response in epileptic patients. This should be considered in prescription of omega-3 fatty acid supplements in these patients. Future studies with larger sample sizes should verify the results of the current study. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
2. The Potential Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Epilepsy Pathogenesis, Endocrine# Metabolic and Immune Disorders - Drug Targets (2021)
3. Dietary Supplementation in Migraine: A Focus on Omega-3 Fatty Acids, Treatments# Nutraceuticals# Supplements# and Herbal Medicine in Neurological Disorders (2023)
Experts (# of related papers)
Other Related Docs