Epilepsy and Vitamin D: A Comprehensive Review of Current Knowledge Publisher Pubmed



Miratashi Yazdi SA¹ ; Abbasi M² ; Miratashi Yazdi SM³
Source: Reviews in the Neurosciences Published:2017

Abstract

Vitamin D has been considered as neurosteroid, and its pivotal role in neuroprotection, brain development, and immunomodulation has been noticed in studies; however, our knowledge regarding its role in neurological disorders is still developing. The potential role of vitamin D in the pathophysiology and treatment of epilepsy, as one the most prevalent neurological disorders, has received less attention in recent years. In this article, we review the possible relationship between vitamin D and epilepsy from different aspects, including the action mechanism of vitamin D in the central nervous system and ecological and epidemiological findings. We also present the outcome of studies that evaluated the level of vitamin D and the impact of administrating vitamin D in epileptic patients or animal subjects. We also review the current evidence on interactions between vitamin D and antiepileptic drugs. © 2017 Walter de Gruyter GmbH, Berlin/Boston.