Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
2-[2-Methyl-5-Phenyl-1-(3,4,5-Trimethoxyphenyl)-1Hpyrrol- 3-Yl]-2-Oxo-N-(Pyridin-4-Yl) Acetamide Publisher



Moghadam ES1 ; Amini M1
Authors

Source: MolBank Published:2018


Abstract

We synthesized 2-[2-methyl-5-phenyl-1-(3,4,5-trimethoxyphenyl)-1H-pyrrol-3-yl]-2-oxo- N-(pyridin-4-yl) acetamide 4 as a novel compound derived from the indibulin and combretastatin scaffolds, which are known anti-mitotic agents, using a multistep reaction. We tested its cytotoxic activity against three breast cancer cell lines, namely, MCF-7, T47-D, and MDA-MB 231 as well as normal cell line NIH-3T3, by 3-(4,5-dimethylthiazoyl-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The biological activity results showed good cytotoxicity on cancerous cell lines (IC50 value 27.7-39.2 µM) and low toxicity on normal cell line (NIH-3T3, IC50 value > 100 µM). © 2018 by the authors.
Related Docs
View other Related Docs
1. Design, Synthesis and Cytotoxicity Evaluation of Indibulin Analogs, Heterocyclic Communications (2018)
2. Design, Synthesis and Anticancer Evaluation of Novel Series of Indibulin Analogues, Medicinal Chemistry (2019)
3. Synthesis and Anti-Breast Cancer Activity of Novel Indibulin Related Diarylpyrrole Derivatives, DARU# Journal of Pharmaceutical Sciences (2019)
Experts (# of related papers)
View all Related Experts
Mohsen Amini (12)
Seyed Nasser Ostad (9)
Other Related Docs
4. 2,4-Disubstituted Quinazoline Derivatives Act As Inducers of Tubulin Polymerization: Synthesis and Cytotoxicity, Anti-Cancer Agents in Medicinal Chemistry (2019)
5. Design, Synthesis and In-Vitro Anti-Cancer Evaluation of Novel Derivatives of 2-(2-Methyl-1,5-Diaryl-1H-Pyrrol-3-Yl)-2-Oxo-N-(Pyridin-3-Yl)Acetamide, Medicinal Chemistry (2020)
6. Triarylpyrazole Derivatives As Potent Cytotoxic Agents; Synthesis and Bioactivity Evaluation Pyrazole Derivatives As Anticancer Agent, Drug Research (2021)
7. Synthesis, Molecular Docking Study, and Cytotoxic Activity of 3,4-Diaryl-5-(4-Pyridinyl)-1,2,4-Oxadiazole, Medicinal Chemistry (2016)
8. Synthesis, Molecular Docking Study, and Cytotoxic Activity of 1,3,5-Triaryl Pyrazole Derivatives, Letters in Drug Design and Discovery (2016)
9. Synthesis and Anticancer Activity of 1,3,5-Triaryl-1H-Pyrazole, Letters in Drug Design and Discovery (2015)
10. Synthesis, Biological Evaluation and Docking Study of New Pyrimidine Compounds As Anticancer Agents, Drug Research (2021)
11. Anticancer Properties of N-Alkyl-2, 4-Diphenylimidazo [1, 2-A] Quinoxalin-1-Amine Derivatives; Kinase Inhibitors, Bioorganic Chemistry (2019)
12. Synthesis and Anticancer Activity of N-(Di/Trimethoxyaryl)-5-Arylisoxazole-3-Carboxamide, Polycyclic Aromatic Compounds (2020)
13. Synthesis, Evaluation of Biological Activity, Docking and Molecular Dynamic Studies of Pyrimidine Derivatives, Letters in Organic Chemistry (2021)
14. An Experimental and Theoretical Approach of a Novel Phosphoramide Containing Naphthoquinone With Potential Cytotoxic and Apoptosis-Inducing Ability, Journal of Molecular Structure (2025)
15. Novel Quinazolin-4(3H)-One Linked to 1,2,3-Triazoles: Synthesis and Anticancer Activity, Chemical Biology and Drug Design (2018)
16. Synthesis and Cytotoxicity of Novel Thioxo-Quinazolino[3,4-A]Quinazolinones, Turkish Journal of Chemistry (2017)
17. Design, Synthesis, Docking Studies, and Biological Activity of Novel Analogs of Cyclophosphamide As Potential Anticancer Agents, Current Medicinal Chemistry (2025)
18. Synthesis, Molecular Docking, and Biological Evaluation of Pyridin-3-Yl-Pyrimidin-2-Yl-Triazole Derivatives As Anti-Cancer Agents, Polycyclic Aromatic Compounds (2024)
19. Novel Quinazolines Bearing 1,3,4-Thiadiazole-Aryl Urea Derivative As Anticancer Agents: Design, Synthesis, Molecular Docking, Dft and Bioactivity Evaluations, BMC Chemistry (2024)
20. Design of Chiral 2-Oxazoline-Based Amino Acid Bioconjugates As Anticancer Agents: Synthesis, in Vitro Anticancer Activity, Admet Prediction With Molecular Docking and Molecular Dynamic Simulation Insights, Archives of Biochemistry and Biophysics (2025)