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Synthesis and Anticancer Activity of 1,3,5-Triaryl-1H-Pyrazole Publisher



Ghadbeigi S1 ; Ostad SN3 ; Shafiee A1 ; Amini M1, 2
Authors

Source: Letters in Drug Design and Discovery Published:2015


Abstract

Previous studies demonstrated that some pyrazole derivatives could be considered as potential anticancer agents. A series of 1,3,5-triaryl-1H-pyrazole derivatives were prepared by the reaction of phenylhydrazin and different chalcones. The previous classic synthesis method was developed for a simpler procedure. The cytotoxicity of these compounds was determined against three cancer cell lines (HT-29), (MCF-7), (AGS) as well as fibroblastic cell line (NIH-3T3) using MTT assay. These biological studies proved that 5f and 5l were the most potent compounds in this series. Furthermore, 5f showed a partial selectivity in cytotoxicity effect between the cancerous and normal cell lines. © 2015 Bentham Science Publishers.
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