Circular Rnas (Circrnas) in Cancer Proliferation: Molecular Interactions and Possible Therapeutic Targets Publisher



Mirzaei S¹ ; Majidinia M² ; Orouei S³ ; Moodi V⁴ ; Salimimoghadam S⁵ ; Entezari M^{6, 7} ; Hushmandi K⁸ ; Ma Z⁹ ; Wang L^{10, 11}
Source: Non-coding RNA Transcripts In Cancer Therapy: Pre-clinical And Clinical Implications Published:2023

Abstract

Circular RNAs (circRNAs) are a member of non-coding RNA transcripts that do not encode proteins, but they exert important biological functions in cells such as regulation of proliferation, migration, differentiation, cell cycle progression, cell death mechanisms, and autophagy. circRNAs have high stability and are reliable biomarkers due to their structure and resistance to degradation by RNase enzymes. circRNA dysregulation has been implicated in disease pathogenesis, especially in cancer. circRNAs affect molecular pathways to regulate the progression of tumor cells and their targeting is important in the treatment of cancer patients. This chapter emphasizes the role of circRNAs in affecting proliferation of tumor cells via regulating apoptosis mechanism, autophagy machinery, and glucose metabolism with a focus on related molecular pathways to pave the way for the development of novel therapeutics for cancer patients. © 2023 World Scientific Publishing Company. All rights reserved.