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Circular Rna; a New Biomarker for Breast Cancer: A Systematic Review Publisher Pubmed



Jahani S1, 2 ; Nazeri E1 ; Majidzadeha K1 ; Jahani M3 ; Esmaeili R1
Authors

Source: Journal of Cellular Physiology Published:2020


Abstract

Circular RNAs (circRNAs) were recently discovered as a looped subset of competing endogenous RNAs, with an ability to regulate gene expression by microRNA sponging. There are several studies on their potential roles in cancer development, such as colorectal cancer and basal cell carcinoma. However, there is still a significant gap in the knowledge about circRNA functions in breast cancer (BC) progression. The current study systematically reviewed circRNA biogenesis and their potential roles as a novel biomarker in BC on published studies of the MEDLINE®/PubMed, Cochrane®, and Scopus® databases. The obtained results showed a general dysregulation of circRNAs expression in BC cells with a cell-type and stage-specific manner. The potential connection between circRNAs and BC cell proliferation, apoptosis, metastasis, and chemotherapy sensitivity and resistance were discussed. © 2020 Wiley Periodicals, Inc.
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