Nutritional Immunology in Lifespan Publisher Pubmed



Fallah M ; Naeini F ; Fahimzad FS ; Nouri A ; Manesh SMR ; Haghighi A ; Ebrahimpourkoujan S
Source: Experimental Gerontology Published:2026

Abstract

Immunonutrition refers to nutritional interventions that can improve immune function. The nutritional contents used in immunocytes include amino acids, vitamins, minerals, and flavonoids.In this study, we examine the oxi-inflamm-aging theory, which illustrates the antioxidant effects of diet, immune system performance, and life span. According to this theory, if vitamin C is consumed in the early stages of life, it can increase life span. The main objective of this study was to investigate the potential role of key immunonutrients in modulating immune system activity and lifespan through antioxidant and anti-inflammatory mechanisms. Vitamin E can reduce the mortality caused by the disease by inhibiting the oxidative damage associated with aging and inducing the P21 signaling pathway as an anti-cancer pathway. Also, vitamin D can reduce aging by increasing the expression of skinhead-1 (SKN-1), a gene of stress response pathways, inhibition of toxicity caused by human β-amyloid, and insolubility of proteins as a molecular pathology of aging. Zinc can adjust the activity of thymus and its hormones, regulating natural killer cells/Natural killer cells (NK/NKT), causing the inherent immune system responses. Moreover, Selenium can reduce the disorders induced by oxidative damage via improving the function of thyroid and immune cells, as well as metabolic and cellular redox homeostasis. Flavonoids also protect against the use of old cells and aging-related phenotypes by protecting nerve cells and metabolic homeostasis, as well as inhibiting old cells and aging phenotypes. However, the findings are still incomplete, and more studies are needed to prove this claim. Therefore, we made this study with careful attention to future issues. © 2025 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC license. http://creativecommons.org/licenses/by-nc/4.0/