Development of 3D-Printed Biocompatible Materials for Meniscus Substitution Publisher



Esmaeili J^{1, 2, 3} ; Rahimnejad M^{4, 5} ; Ur Rehman MR⁶ ; Beheshtizadeh N^{7, 8} ; Barati A¹
Source: Cartilage Tissue and Knee Joint Biomechanics: Fundamentals# Characterization and Modelling Published:2023

Abstract

This chapter highlights the recent progress in developing 3D-printed materials suitable for meniscus reconstruction. Similar to other organs and tissue, the meniscus is vulnerable and, in some cases, it is difficult to be healed. 3D printing gives a promising future to overcome challenges for patients with a meniscus injury. The role of biomaterials in the fabrication of 3D-printed scaffolds for meniscus substitution is undeniable. In other words, the mechanical, physicochemical, and biological properties of a meniscus-like scaffold can be optimized by changing the employed biomaterials. To achieve optimal properties, the combination of synthetic and natural biomaterials has always been recommended. Apart from these, scaffold geometry, optimal cell line selection, cell source, and growth factors can all stimulate cell differentiation into fibrocartilage, to create a suitable substitute for meniscus. By the way, creating a unique substitute for meniscus has a long way ahead and there are still challenges that are remained unsolved. As a result, the meniscus, despite its simple appearance, still needs further studies to establish a suitable substitute with suitable biological properties, which could be due to the location of this tissue and the constant pressure. © 2024 Elsevier Inc. All rights reserved.