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Enhancing in Vitro Osteogenic Differentiation of Mesenchymal Stem Cells Via Sustained Dexamethasone Delivery in 3D-Printed Hybrid Scaffolds Based on Polycaprolactone-Nanohydroxyapatite/Alginate-Gelatin for Bone Regeneration Publisher



Noory P1 ; Farmani AR2 ; Ai J1 ; Bahrami N1, 3 ; Bayat M3 ; Ebrahimibarough S1 ; Farzin A4 ; Shojaie S5 ; Hajmoradi H6 ; Mohamadnia A7, 8 ; Goodarzi A2
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Source: Journal of Biological Engineering Published:2025


Abstract

Layer-by-layer 3D-printing was effectively applied to prepare a biomimetic combined structure composing hard composite (PCL-nHA) and soft hydrogel (Alg-Gel). 3D-printing scaffolds were used to control the delivery of dexamethasone (DEX) to enhance bone repair. DEX-loaded scaffolds promoted osteogenic differentiation and mineralization of human endometrial mesenchymal stem cells (hEnMSCs). © The Author(s) 2025.
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