Biosensors: The Nanomaterial-Based Method in Detection of Human Gut Microbiota Publisher

Summary: This review highlights the potential of nanomaterial-based biosensors in monitoring gut microbiota for improved cancer treatment. Are these tools the future of clinical diagnostics? #Oncology #Biosensors

Ayati MH^{1, 2} ; Arajkhodaei M^{1, 3} ; Haghgouei T⁴ ; Ahmadalipour A^{5, 6} ; Mobed A^{1, 4, 5} ; Sanaie S¹
Source: Materials Chemistry and Physics Published:2023

Abstract

The gut microbiota has emerged as an important aspect of clinical oncology. The role of microbiota in cancer goes beyond the risks and causes of cancer. Microbiotas are currently known to act at the local epithelial level of the intestine and alter the immune response of intestinal and extra-intestinal tumors. As probiotics are increasingly used in functional foods and pharmaceuticals, rapid and sensitive monitoring of probiotics is important for quality, purity, and safety management. Due to the weaknesses and limitations of routine microbiological techniques, developing advanced state-of-the-art methods is one of the main goals of researchers. One of the most critical and progressive areas is the nanomaterial-based method. Biosensors are one of the most advanced methods based on nanomaterials. While biosensing technology for the human gut flora has the potential to transform the clinical diagnosis, point-of-care (POC) biosensors that directly detect microbial community disruptions are not currently available in clinical practice. This review study aimed to explore the potential of biosensors in identifying the human gut flora to achieve the best techniques for the first time. © 2023 Elsevier B.V.