Mitochondria Determine Response to Anti-Programmed Cell Death Protein-1 (Anti-Pd-1) Immunotherapy: An Evidence-Based Hypothesis

Mitochondria Determine Response to Anti-Programmed Cell Death Protein-1 (Anti-Pd-1) Immunotherapy: An Evidence-Based Hypothesis Publisher Pubmed

Akbari H^{1, 2} ; Taghizadehhesary F³ ; Bahadori M⁴

Source: Mitochondrion Published:2022

Abstract

Immunotherapy based on programmed cell death protein-1 (PD-1) is a promising approach in oncology. However, a significant fraction of patients remain unresponsive. Therefore, it is imperative to clarify the relevant predictive factors. A decrease in cellular adenosine triphosphate (c-ATP) level can predispose to cellular dysfunction. ATP is a prerequisite for proper T cell migration and activation. Therefore, a decrease in the c-ATP level impairs T cell function and promotes cancer progression. This article gives an overview of the potential predictive factors of PD-1 blockade. Besides, it highlights the pivotal role of mitochondria in response to anti-PD-1 therapies. © 2021 Elsevier B.V. and Mitochondria Research Society

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Style	Citing Format
MLA	Akbari H, Taghizadehhesary F, Bahadori M. "Mitochondria Determine Response to Anti-Programmed Cell Death Protein-1 (Anti-Pd-1) Immunotherapy: An Evidence-Based Hypothesis." Mitochondrion, vol. 62, no. , 2022, pp. 151-158.
APA	Akbari H, Taghizadehhesary F, Bahadori M (2022). Mitochondria Determine Response to Anti-Programmed Cell Death Protein-1 (Anti-Pd-1) Immunotherapy: An Evidence-Based Hypothesis. Mitochondrion, 62(), 151-158.
Chicago	Akbari H, Taghizadehhesary F, Bahadori M. "Mitochondria Determine Response to Anti-Programmed Cell Death Protein-1 (Anti-Pd-1) Immunotherapy: An Evidence-Based Hypothesis." Mitochondrion 62, no. (2022): 151-158.
Harvard	Akbari H, Taghizadehhesary F, Bahadori M (2022) 'Mitochondria Determine Response to Anti-Programmed Cell Death Protein-1 (Anti-Pd-1) Immunotherapy: An Evidence-Based Hypothesis', Mitochondrion, 62(), pp. 151-158.
Vancouver	Akbari H, Taghizadehhesary F, Bahadori M. Mitochondria Determine Response to Anti-Programmed Cell Death Protein-1 (Anti-Pd-1) Immunotherapy: An Evidence-Based Hypothesis. Mitochondrion. 2022;62():151-158.
BibTex	@article{ author = {Akbari H and Taghizadehhesary F and Bahadori M}, title = {Mitochondria Determine Response to Anti-Programmed Cell Death Protein-1 (Anti-Pd-1) Immunotherapy: An Evidence-Based Hypothesis}, journal = {Mitochondrion}, volume = {62}, number = {}, pages = {151-158}, year = {2022} }
RIS	TY - JOUR AU - Akbari H AU - Taghizadehhesary F AU - Bahadori M TI - Mitochondria Determine Response to Anti-Programmed Cell Death Protein-1 (Anti-Pd-1) Immunotherapy: An Evidence-Based Hypothesis JO - Mitochondrion VL - 62 IS - SP - 151 EP - 158 PY - 2022 ER -

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