Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Molecular Diagnosis of Human Cutaneous Leishmaniasis and Identification of the Causative Leishmania Species in Iran: A Narrative Review
Homa Hajjaran
Homa Hajjaran

Professor of Medical Parasitology

Department Medical Parasitology and Mycology

School of Public Health

Tehran University of Medical Sciences

All Documents
1. First Report of Leishmania Rna Virus 2 and Its High Genetic Diversity in Cutaneous Leishmaniasis Cases From Ilam Province, Iran, BMC Medical Genomics (2025)
2. The Expression Profile of Inflammatory Micrornas in Leishmania Major Infected Human Macrophages; Mining the Effects of Leishmania Rna Virus, BMC Microbiology (2025)
3. Transcriptional Alterations of Virulence Factors in Leishmania Major Clinical Isolates Harboring Leishmania Rna Virus 2 (Lrv2), BMC Infectious Diseases (2025)
4. Upregulation of Antioxidant Genes in Antimony-Resistant Leishmania Tropica Clinical Isolates, Molecular Biology Reports (2025)
5. Upregulation of Antioxidant Genes in Antimony-Resistant Leishmania Tropica Clinical Isolates, Molecular Biology Reports (2025)
6. A Geomedical Survey: Is There an Association Between Climatic Conditions and Leishmania Species Distribution in Iran During the Years 1999–2021?, Acta Parasitologica (2024)
7. Emergence of Coinfection With Visceral Leishmania Infantum in Covid-19 Patients: A Case‒Control Field Study in an Endemic Area of Visceral Leishmaniasis in Iran, BMC Infectious Diseases (2024)
8. Exploring the Significant Genetic Diversity of Iranian Isolates of Leishmania Rna Virus 2 Using Whole Genome Sequence Analysis, BMC Infectious Diseases (2024)
9. Genetic Diversity and Phylogenetic Study of Leishmania Species in Iran by Multilocus Sequence Typing, Iranian Journal of Parasitology (2024)
10. Insights Into the Trypanothione System in Antimony-Resistant and Sensitive Leishmania Tropica Clinical Isolates, Acta Tropica (2024)
11. Molecular Tracking of Leishmania Major in an Archived Rattus Norvegicus Spleen Sample in Iran: A Case Report, Iranian Journal of Parasitology (2024)
12. Recognition of Immunoreactive Proteins in Leishmania Infantum Amastigote-Like and Promastigote Using Sera of Visceral Leishmaniasis Patients: A Preliminary Study, Acta Parasitologica (2024)
13. Amphotericin B-Loaded Extracellular Vesicles Derived From Leishmania Major Enhancing Cutaneous Leishmaniasis Treatment Through in Vitro and in Vivo Studies, Iranian Journal of Parasitology (2023)
14. Assessment of Genetic Markers for Multilocus Sequence Typing (Mlst) of Fasciola Isolates From Iran, Veterinary Medicine and Science (2023)
15. Effect of Leishmania Rna Virus 2 on Virulence Factors and Cytokines Gene Expression in a Human Macrophage Infected With Leishmania Major: A Preliminary Study, Experimental Parasitology (2023)
16. In Vitro Study on Four Types of Commercial Lectins on Leishmania Infantum, L. Major and L. Tropica With Stage-Specific Binding and Leishmania Species Identification, Iranian Journal of Parasitology (2023)
17. Proteomics Investigation of Human Sera for Determination of Postoperative Indicators of Pulmonary Cystic Echinococcosis, Journal of Cardiothoracic Surgery (2023)
18. The Association of Human Leucocyte Antigen (Hla) Class I and Ii Genes With Cutaneous and Visceral Leishmaniasis in Iranian Patients: A Preliminary Case-Control Study, Iranian Journal of Parasitology (2023)
19. The Effects of Leishmania Rna Virus 2 (Lrv2) on the Virulence Factors of L. Major and Pro-Inflammatory Biomarkers: An in Vitro Study on Human Monocyte Cell Line (Thp-1), BMC Microbiology (2023)
20. Visceral Leishmaniasis in Iran: An Update on Epidemiological Features From 2013 to 2022, Iranian Journal of Parasitology (2023)
21. A Sero-Epidemiological Study on Visceral Leishmaniasis Among Volunteer Children and Adults in Rural Areas of Shahroud, Iran 2018-2019, Journal of Arthropod-Borne Diseases (2022)
22. Development of an Indirect Fluorescent Antibody (Ifa) Assay for the Detection of Leishmania Rna Virus 2 (Lrv2) in Leishmania Parasites, Iranian Journal of Parasitology (2022)
23. Identification and Phylogenic Analysis of Leishmania Species Among Patients and Reservoir Hosts Based on N-Acetylglucosamine-1-Phosphate Transferase Gene in Central Iran, Annals of Parasitology (2022)
24. Identification and Phylogenic Analysis of Leishmania Species Among Patients and Reservoir Hosts Based on N-Acetylglucosamine-1-Phosphate Transferase Gene in Central Iran, Annals of Parasitology (2022)
25. Leishmania Rna Virus 2 (Lrv2) Exacerbates Dermal Lesions Caused by Leishmania Major and Comparatively Unresponsive to Meglumine Antimoniate Treatment, Experimental Parasitology (2022)
26. Leishmania Spp. Infection in Rhombomys Opimus and Meriones Libycus As Main Reservoirs of Zoonotic Cutaneous Leishmaniasis in Central Parts of Iran: Progress and Implications in Health Policy, Acta Tropica (2022)
27. Leishmania Spp. Infection in Rhombomys Opimus and Meriones Libycus As Main Reservoirs of Zoonotic Cutaneous Leishmaniasis in Central Parts of Iran: Progress and Implications in Health Policy, Acta Tropica (2022)
28. Molecular Identification of Leishmania Rna Virus in Cutaneous Leishmaniasis Patients and Rodent Reservoirs in Isfahan Province, Iran, Infection# Genetics and Evolution (2022)
29. Molecular Identification of Leishmania Rna Virus in Cutaneous Leishmaniasis Patients and Rodent Reservoirs in Isfahan Province, Iran, Infection, Genetics and Evolution (2022)
30. Overexpression of Iron Super Oxide Dismutases A/B Genes Are Associated With Antimony Resistance of Leishmania Tropica Clinical Isolates, Iranian Journal of Parasitology (2022)
31. Successful Isolation of Leishmania Rna Virus (Lrv) From Leishmania Major in a Cutaneous Leishmaniasis Focus in Central Iran: An Update on Cases, Acta Parasitologica (2022)
32. Validation of a Mixture of Rk26 and Rk39 Antigens From Iranian Strain of Leishmania Infantum to Detect Anti-Leishmania Antibodies in Human and Reservoir Hosts, Scientific Reports (2022)
33. A Comparative Study of Nested-Pcr and Direct Agglutination Test (Dat) for the Detection of Leishmania Infantum Infection in Symptomatic and Asymptomatic Domestic Dogs, BMC Research Notes (2021)
34. Identification of Immunodominant Proteins of Leishmania Infantum by Immunoproteomics to Evaluate a Recombinant Multi-Epitope Designed Antigen for Serodiagnosis of Human Visceral Leishmaniasis, Experimental Parasitology (2021)
35. In Vitro and in Vivo Anti-Parasitic Activity of Artemisinin Combined With Glucantime and Shark Cartilage Extract on Iranian Strain of Leishmania Major (Mrho/Ir/75/Er), Jundishapur Journal of Microbiology (2021)
36. Interaction Between Chitosan and Chloroquine Against Plasmodium Berghei and P. Falciparum Using In-Vivo and In-Vitro Tests, Iranian Journal of Parasitology (2021)
37. Molecular Identification of Leishmania Species in an Outbreak of Re-Emerged Cutaneous Leishmaniasis in Southwestern Iran During 2015-2016, Archives of Clinical Infectious Diseases (2021)
38. Proteomic Characterization of Hydatid Cyst Fluid: Two-Dimensional Electrophoresis (2-De) Setup Through Optimizing Protein Extraction, BMC Research Notes (2021)
39. Taxonomy, Population Structure and Genetic Diversity of Iranian Leishmania Strains of Cutaneous and Visceral Leishmaniasis, Acta Parasitologica (2021)
40. The Geographical Distribution of Human Cutaneous and Visceral Leishmania Species Identified by Molecular Methods in Iran: A Systematic Review With Meta-Analysis, Frontiers in Public Health (2021)
41. Comparative Mitochondrial Proteomics of Leishmania Tropica Clinical Isolates Resistant and Sensitive to Meglumine Antimoniate, Parasitology Research (2020)
42. Molecular and Seroepidemiological Survey of Visceral Leishmaniasis in Owned Dogs (Canis Familiaris) in New Foci of Rural Areas of Alborz Province, Central Part of Iran: A Cross-Sectional Study in 2017, Journal of Arthropod-Borne Diseases (2020)
43. Molecular Identification of Leishmania Species Isolated From Patients With Cutaneous Leishmaniosis in Gonbad Kavoos, Northeastern of Iran Using Hsp70 and Its-Based Pcr-Rflp, Annals of parasitology (2020)
44. Presence and Diversity of Leishmania Rna Virus in an Old Zoonotic Cutaneous Leishmaniasis Focus, Northeastern Iran: Haplotype and Phylogenetic Based Approach, International Journal of Infectious Diseases (2020)
45. Probability of False-Negative Results in Microscopical Detection of Cutaneous Leishmaniasis: More Accurate Screening by Kdna-Pcr During Epidemiological Survey, Journal of Parasitic Diseases (2020)
46. The Rk39 Antigen From an Iranian Strain of Leishmania Infantum: Detection of Anti-Leishmania Antibodies in Humans and Dogs, Iranian Journal of Parasitology (2020)
47. Treatment Failure in Cutaneous Leishmaniasis Patients Referred to the School of Public Health, Tehran University of Medical Sciences During 2008-2017, Journal of Arthropod-Borne Diseases (2020)
48. A Comparative Evaluation of Regulatory T Cells Profile Among Acute and Chronic Cutaneous Leishmaniasis Using Flow Cytometry, Iranian Journal of Parasitology (2019)
49. Gene Expression Analysis of Antimony Resistance in Leishmania Tropica Using Quantitative Real-Time Pcr Focused on Genes Involved in Trypanothione Metabolism and Drug Transport, Archives of Dermatological Research (2019)
50. Identification of Alleles in the Msp1 Gene Related to Complicated Malaria in Patients Infected With Plasmodium Falciparum in Southeast of Iran, Journal of Arthropod-Borne Diseases (2019)
51. Mitochondrial Proteome Profiling of Leishmania Tropica, Microbial Pathogenesis (2019)
52. Western Blot Analysis of Leishmania Infantum Antigens in Sera of Patients With Visceral Leishmaniasis, Iranian Journal of Parasitology (2019)
53. Comparison of P27 Gene Expression of Promastigote and Amastigote Forms of Leishmania Major (Mrho/Ir/75/Er) by Real-Time Rt-Pcr, Iranian Journal of Parasitology (2018)
54. Epidemiology of Fascioliasis in Kermanshah Province, Western Iran, Iranian Journal of Public Health (2018)
55. High Resolution Melting Analysis As an Accurate Method for Identifying Leishmania Infantum in Canine Serum Samples, Journal of Vector Borne Diseases (2018)
56. Identification of Leishmania Species Using N-Acetylglucosamine-1-Phosphate Transferase Gene in a Zoonotic Cutaneous Leishmaniasis Focus of Iran, Journal of Vector Borne Diseases (2018)
57. Molecular Identification of Agents of Human Cutaneous Leishmaniasis and Canine Visceral Leishmaniasis in Different Areas of Iran Using Internal Transcribed Spacer 1 Pcr-Rflp, Journal of Arthropod-Borne Diseases (2018)
58. Response Letter to the Editor in Reference to Letter to the Editor About “Molecular Characterization of Animal Fasciola Spp. Isolates From Kermanshah, Western Iran”, Iranian Journal of Public Health (2018)
59. Cloning of K26 Hydrophilic Antigen From Iranian Strain of Leishmania Infantum, Iranian Journal of Public Health (2017)
60. Correlation Between Clinical Responses With the Drug-Susceptibility of Parasites in Iranian Cutaneous Leishmaniasis Caused by Leishmania Major, Tropical Biomedicine (2017)
61. Feline Leishmaniosis Due to Leishmania Infantum in Northwest Iran: The Role of Cats in Endemic Areas of Visceral Leishmaniosis, Veterinary Parasitology: Regional Studies and Reports (2017)
62. Genetic Diversity and Phylogenetic Analysis of the Iranian Leishmania Parasites Based on Hsp70 Gene Pcr-Rflp and Sequence Analysis, Korean Journal of Parasitology (2017)
63. Molecular Characterization and Analysis of 16S Ribosomal Dna in Some Isolates of Demodex Folliculorum, Iranian Journal of Parasitology (2017)
64. Molecular Identification of Leishmania Species in a Re-Emerged Focus of Cutaneous Leishmaniasis in Varamin District, Iran, Journal of Arthropod-Borne Diseases (2017)
65. Canine Visceral Leishmaniasis in Wild Canines (Fox, Jackal, and Wolf) in Northeastern Iran Using Parasitological, Serological, and Molecular Methods, Journal of Arthropod-Borne Diseases (2016)
66. Detection and Molecular Identification of Leishmania Rna Virus (Lrv) in Iranian Leishmania Species, Archives of Virology (2016)
67. Expression Analysis of Activated Protein Kinase C Gene (Lack1) in Antimony Sensitive and Resistant Leishmania Tropica Clinical Isolates Using Real-Time Rt-Pcr, International Journal of Dermatology (2016)
68. Expression Analysis of Viscerotropic Leishmaniasis Gene in Leishmania Species by Real-Time Rt-Pcr, Acta Parasitologica (2016)
69. Inter- and Intraspecific Variations of Leishmania Strains Isolated From Patients With Cutaneous and Visceral Leishmaniases in Fars Province, South of Iran, Iranian Journal of Medical Sciences (2016)
70. Molecular Analysis of Isolates of the Cestode Rodentolepis Nana From the Great Gerbil, Rhombomys Opimus, Journal of Helminthology (2016)
71. Molecular Characterization of Animal Fasciola Spp. Isolates From Kermanshah,Western Iran, Iranian Journal of Public Health (2016)
72. Molecular Evaluation of a Case of Visceral Leishmaniasis Due to Leishmania Tropica in Southwestern Iran, Iranian Journal of Parasitology (2016)
73. Risk Mapping and Situational Analysis of Cutaneous Leishmaniasis in an Endemic Area of Central Iran: A Gis-Based Survey, PLoS ONE (2016)
74. Seroprevalence of Toxoplasma Gondii Infection in Domestic Dogs in an Area From Northwest of Iran: A Cross-Sectional Study Using Immunodominant Surface Antigen 1 (Sag1), Journal of Parasitic Diseases (2016)
75. Therapeutic Effect of Scrophularia Striata Ethanolic Extract Against Localized Cutaneous Leishmaniasis Caused by Leishmania Major (Mrho/Ir/75/Er), Iranian Journal of Public Health (2016)
76. Comparative Proteomic Profiling of Leishmania Tropica: Investigation of a Case Infected With Simultaneous Cutaneous and Viscerotropic Leishmaniasis by 2-Dimentional Electrophoresis and Mass Spectrometry, Iranian Journal of Parasitology (2015)
77. Comparison of Proteome Profiling of Two Sensitive and Resistant Field Iranian Isolates of Leishmania Major to Glucantime® by 2-Dimensional Electrophoresis, Iranian Journal of Parasitology (2015)
78. Comparison of the Proteome Profiling of Iranian Isolates of Leishmania Tropica, L. Major and L. Infantum by Two-Dimensional Electrophoresis (2-De) and Mass-Spectrometry, Iranian Journal of Parasitology (2015)
79. Dna Sequence Polymorphism of the Lactate Dehydrogenase Genefrom Iranian Plasmodium Vivax and Plasmodium Falciparum Isolates, Iranian Journal of Parasitology (2015)
80. Molecular and Parasitological Study of Cutaneous Leishmaniasis in Bushehr Province, Southwest of the Islamic Republic of Iran: A Cross-Sectional Study During 2009–2012, Journal of Parasitic Diseases (2015)
81. Visceral Leishmaniasis in Rural Areas of Alborz Province of Iran and Implication to Health Policy, Korean Journal of Parasitology (2015)