Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Identification of New Dna Gyrase Inhibitors Based on Bioactive Compounds From Streptomyces: Structure-Based Virtual Screening and Molecular Dynamics Simulations Approaches
Zargham Sepehrizadeh
Zargham Sepehrizadeh

Professor of Pharmaceutical Biotechnology

Department Pharmaceutical Biotechnology

School of Pharmacy

Biotechnology Research Center

Tehran University of Medical Sciences

All Documents
1. A Novel Broad-Spectrum Bacteriophage Cocktail Against Methicillin-Resistant Staphylococcus Aureus: Isolation, Characterization, and Therapeutic Potential in a Mastitis Mouse Model, PLoS ONE (2025)
2. Decoding Shared Molecular Mechanisms of Sars-Cov-2 and Hcov-Oc43 in Covid-19 Neurological Manifestations: A Systems Biology Approach, Gene Reports (2025)
3. Characterization and Genome Analysis of a Broad Host Range Lytic Phage Vb_Sens_Tums_E19 Against Salmonella Enterica and Its Efficiency Evaluation in the Liquid Egg, Canadian Journal of Microbiology (2024)
4. Decoding the Structure–Function Relationship of the Muramidase Domain in E. Coli O157.H7 Bacteriophage Endolysin: A Potential Building Block for Chimeric Enzybiotics, Protein Journal (2024)
5. Evaluating the Effectiveness and Safety of a Novel Phage Cocktail As a Biocontrol of Salmonella in Biofilm, Food Products, and Broiler Chicken, Frontiers in Microbiology (2024)
6. Optimization of Keratin Sponge Preparation Conditions for Hemostatic Application Using Response Surface Methodology (Rsm), Journal of Polymers and the Environment (2024)
7. Isolation, Characterization, and Genome Analysis of a Broad Host Range Salmonella Phage Vb_Sens_Tums_E4: A Candidate Bacteriophage for Biocontrol, Veterinary Research Communications (2023)
8. Isolation, Characterization, and Genomic Analysis of Vb_Paep_Tums_P121, a New Lytic Bacteriophage Infecting Pseudomonas Aeruginosa, Archives of Virology (2023)
9. Isolation, Characterization, and Genomic Analysis of Vb_Paes_Tums_P81, a Lytic Bacteriophage Against Pseudomonas Aeruginosa, Virus Genes (2023)
10. The Cytotoxicity of Tellurium Nanoparticles on Different Cell Lines and Their in Vivo Anticancer Effects in an Animal Model, Middle East Journal of Cancer (2023)
11. Potentiation of the Therapeutic Effect of Intravesical Bcg Through Synthetic and Biogenic Selenium Nanoparticles in a Nitrosamine-Induced Bladder Cancer Mouse Model, Advances in Cancer Biology - Metastasis (2022)
12. Comparison of Cytokine Expression in Human Pbmcs Stimulated With Normal and Heat-Shocked Lactobacillus Plantarum Cell Lysate, Probiotics and Antimicrobial Proteins (2021)
13. Expression of Recombinant G-Csf Receptor Domains and Their Inhibitory Role on G-Csf Function, Research in Pharmaceutical Sciences (2020)
14. Expression of Recombinant G-Csf Receptor Domains and Their Inhibitory Role on G-Csf Function, Research in Pharmaceutical Sciences (2020)
15. Nanobodies in Human Infections: Prevention, Detection, and Treatment, Immunological Investigations (2020)
16. Reporting a Transcript From Iranian Viola Tricolor, Which May Encode a Novel Cyclotide-Like Precursor: Molecular and in Silico Studies, Computational Biology and Chemistry (2020)
17. Periovax3, a Key Antigenic Determinant With Immunoprotective Potential Against Periodontal Pathogen, Microbial Pathogenesis (2019)
18. A Minireview on the in Vitro and in Vivo Experiments With Anti-Escherichia Coli O157:H7 Phages As Potential Biocontrol and Phage Therapy Agents, International Journal of Food Microbiology (2017)
19. Genetic Polymorphism of Plasmodium Vivax Duffy Binding Protein in Malarious Areas in Southeastern of Iran, Journal of Parasitic Diseases (2017)
20. Identification and in Vitro Characterization of Novel Nanobodies Against Human Granulocyte Colony-Stimulating Factor Receptor to Provide Inhibition of G-Csf Function, Biomedicine and Pharmacotherapy (2017)
21. Enhancing Activity and Thermostability of Lipase a From Serratia Marcescens by Site-Directed Mutagenesis, Enzyme and Microbial Technology (2016)
22. Gene Expression Profiling Revealed Overexpression of Vesicle Amine Transport Protein-1 (Vat-1) As a Potential Oncogene in Gastric Cancer, Indian Journal of Biotechnology (2016)
23. Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology, Nano Biomedicine and Engineering (2016)
24. Bacterial Expression and Characterization of an Active Recombinant Lipase a From Serratia Marcescens With Truncated C-Terminal Region, Journal of Molecular Catalysis B: Enzymatic (2015)
25. Comparison of Sybr Green and Taqman Real-Time Pcr Methods for Quantitative Detection of Residual Cho Host-Cell Dna in Biopharmaceuticals, Biologicals (2015)
26. Dose-Response Relationship Study of Selenium Nanoparticles As an Immunostimulatory Agent in Cancer-Bearing Mice, Archives of Medical Research (2015)
27. Identification of Novel Genes Involved in Gastric Carcinogenesis by Suppression Subtractive Hybridization, Human and Experimental Toxicology (2015)
28. Th1 Immune Response Induction by Biogenic Selenium Nanoparticles in Mice With Breast Cancer: Preliminary Vaccine Model, Iranian Journal of Biotechnology (2015)
29. The Antimicrobial Effects and Metabolomic Footprinting of Carboxyl-Capped Bismuth Nanoparticles Against Helicobacter Pylori, Applied Biochemistry and Biotechnology (2014)
30. Biosynthesis of Bismuth Nanoparticles Using Serratia Marcescens Isolated From the Caspian Sea and Their Characterisation, IET Nanobiotechnology (2012)
31. Ligation Independent Cloning of Polycistronic, Genetically Modified, Humab4d5-8 F (Ab') 2, in Bacterial Plasmid, Avicenna Journal of Medical Biotechnology (2012)