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Helicobacter Pylori Seropositivity in Iranian Patients With Vitiligo: A Case-Control Study Publisher

Summary: Study finds H. pylori infection may worsen vitiligo, suggesting a role in disease progression. #Vitiligo #Infection

Aghaei M1 ; Aghaei S2 ; Iraji F3 ; Nilforoushzadeh MA4 ; Hosseini SM5 ; Shahmoradi Z6 ; Hejazi SH7
Authors

Source: Iranian Journal of Dermatology Published:2024


Abstract

Background: Vitiligo is an autoimmune disease of the skin that affects both sexes and people of any age. The genetic and environmental factors are involved in the vitiligo etiology. Helicobacter pylori (H. pylori) has an important role in vitiligo progression. Therefore, the present study evaluated H. pylori seropositivity in vitiligo patients compared to healthy individuals. Method: H. pylori infection was investigated in 210 vitiligo patients and 127 sex-and age-matched healthy controls using Enzyme-Linked Immunosorbent Assay (ELISA) test. The data was analyzed using SPSS software version 20.0, and the groups were compared using T-test and ANOVA tests. P < 0.05 was considered statistically significant. Resul t s: Vi t i l i go pat i ent s had hi gher medi an l evel s of I gG (29.68 ± 28.28 RU/mL) than (19.08 ± 20.12 RU/mL) in healthy controls (P < 0.000). Moreover, there was no significant difference between groups based on the level of IgM (P < 0.207). In the vitiligo group, IgG or IgM means were different compared to age (P < 0.33)/ (P < 0.017) and early symptoms (P < 0.00) (P < 0.02), respectively. Unlike IgG, there was a significant difference between the mean level of IgM, the onset age of vitiligo (P < 0.022), and the duration of the disease (P < 0.05). Moreover, males and females with vitiligo had a higher seropositivity to H. pylori antibodies than the control group. Conclusion: Vitiligo was found to be significantly associated with H. pylori in Iranian patients. Therefore, it seemed probable that H. pylori had an important role in the initiation or progression of disease activity in vitiligo. © Iranian Journal of Dermatology.
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