Brca 1/2 Mutations and Risk of Uterine Cancer: A Systematic Review and Meta-Analysis Publisher Pubmed



Zakerinasab F¹ ; Behfar Q² ; Parsaee R³ ; Zadeh RH⁴ ; Foroughi E⁵ ; Amirbeik A⁶ ; Ahmadi G¹
Source: BMC Genomic Data Published:2024

Abstract

Purpose: In this study, we aim to investigate the association between BRCA1/2 mutation and uterine cancer incidence. Material and method: We systematically searched three databases including PubMed, Scopus, and Google Scholar up to August 2023; and reviewed 23 cohorts and cross-sectional studies to explore the association between BRCA1/2 mutations and uterine cancer incidence. Results: This systematic review comprised a total of 21 cohort studies and 2 cross-sectional studies after the screening process. According to meta-analysis the prevalence of the BRCA1/2 gene in patients with uterine cancer was 0.02 (95%CI = [0.01,0.03], P < 0.01, I2 = 94.82%) Conclusions: Our meta-analysis investigates a 2% prevalence of BRCA1/2 mutation in patients with uterine cancer. Patients with BRCA1/2 mutations might be more conscious of uterine malignancies. © 2024, The Author(s).