Isfahan University of Medical Sciences

Science Communicator Platform

Share By
Molecular Signatures of Breast Cancer in the Iranian Population: A Review of Cell Growth and Cell Cycle Regulators Publisher Pubmed



Mashayekh Z ; Broojeni JV ; Fard RF ; Vallian S
Authors

Source: Journal of Cancer Research and Clinical Oncology Published:2025


Abstract

The mortality rate of breast cancer remains relatively high in the Iranian population, with approximately 4810 deaths reported in 2020 (GLOBOCAN). This elevated fatality rate has been predominantly attributed to delays in diagnosis. In recent years, substantial research efforts have been directed toward elucidating cellular markers associated with breast cancer within this population. To this end, a systematic literature search was undertaken across both international and national databases, including PubMed, Scopus, IranMedex, and Magiran, covering the period from 2019 to 2024. The review synthesized data from studies encompassing a total of 15,318 Iranian breast cancer patients. The aggregated evidence provides comprehensive insights into cellular growth and cell cycle regulation markers implicated in breast cancer, thereby offering potential to inform the development of population-specific molecular diagnostic and prognostic strategies. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Socioeconomic Disparities Impacting Breast Cancer Care and Survival in Iran, Scientific Reports (2025)
2. Cancer in Iran 2008 to 2025: Recent Incidence Trends and Short-Term Predictions of the Future Burden, International Journal of Cancer (2021)
3. Incidence, Prevalence, and Mortality Rate of Gastrointestinal Cancer in Isfahan, Iran: Application of the Miamod Method, Asian Pacific Journal of Cancer Prevention (2016)
Experts (# of related papers)
View all Related Experts
Mohammad Reza Maracy (2)
Marjan Mansourian (1)
Other Related Docs
4. Incidence of Breast and Cervical Intraepithelial Lesions: Results of a Screening Program for Women, Journal of Obstetrics, Gynecology and Cancer Research (2022)
5. The Global, Regional, and National Burden of Cancer, 1990–2023, With Forecasts to 2050: A Systematic Analysis for the Global Burden of Disease Study 2023, The Lancet (2025)
6. Survival Analysis of Iranian Patients With Breast Cancer Using Joint Frailty Model With a Cure Rate, Middle East Journal of Cancer (2021)
7. Evaluation of Risk Factors in Developing Breast Cancer With Expectation Maximization Algorithm in Data Mining Techniques, Journal of Medical Imaging and Health Informatics (2016)
8. Association of Fatty Acid Synthase (Fasn), Atp-Citrate Lyase (Acly), and Acyl-Coenzyme a Synthetase Long-Chain 4 (Acsl4) Expression and Human Epidermal Growth Factor Receptor 2 (Her2) Status With Metastasis and Survival in Breast Cancer: A Five-Year Follow-Up, Research in Pharmaceutical Sciences (2026)
9. Clinical Relevance of Circulating Biomarkers in Breast Cancer Metastasis Detection: Insights From Liquid Biopsy Technology, Research in Pharmaceutical Sciences (2025)
10. National Surveillance of Cancer Survival in Iran (Irancansurv): Analysis of Data of 15 Cancer Sites From Nine Population-Based Cancer Registries, International Journal of Cancer (2022)
11. Relations of Disease-Free Survival and Overall Survival With Age and Primary Metastases in Patients With Breast Cancer, Journal of Isfahan Medical School (2013)
12. The Most Common Cancers in Iranian Women, Iranian Journal of Public Health (2009)
13. Relative Survival and Trends in Patients With Prostate and Breast Cancers in Isfahan County, Iran, 2014–2021: A Population-Based Retrospective Cohort Study Using Join Point Regression; [یسرربیاقبیبسنودنوراقبردنارامیبالتبمهبیاهناطرستاتسورپوناتسپردناتسرهش ناهفصازا:لاس1393-1400کیهعلاطمتروهوکهتشذگرگنینتبمربتیعمجابهدافتسازا نیوجتنیوپ], Iranian Journal of Epidemiology (2026)