Dramatic Dietary Fat Reduction Is Feasible for Breast Cancer Patients: Results of the Randomised Study, Wins (Uk) - Stage 1 Publisher Pubmed



Parry BM¹ ; Milne JM¹ ; Yadegarfar G^{2, 3} ; Rainsbury RM¹
Source: European Journal of Surgical Oncology Published:2011

Abstract

Introduction: The influence of dietary fat on breast tumour growth 1 and, more recently, on treatment outcomes, 2,3 suggests an important role for dietary advice in the future health of breast cancer patients. The Women's Intervention Nutrition Study (UK) - Stage 1 assessed the feasibility of achieving and maintaining a ≥50% reduction in reported fat intake in postmenopausal, early stage breast cancer patients in the UK. Method: This study recruited patients in South-east England between 2000 and 2005. They were randomly allocated into two groups. Group 1 (n = 54), received specific dietary counselling to halve their reported fat intake and maintain this low fat intake. Group 2 (n = 53) received healthy eating advice only. Dietitian-led group sessions provided support for women in both groups over 2 years. 4 Validated four-day diaries were used to measure intake. Data analysis used Generalised Linear Model (GLM) for repeated measures and logistic regression. Results: A significantly greater proportion of women in Group 1 reported a fat intake reduction of ≥50% at 3 months (p < .001) and 24 months (p < .001) than in Group 2. The size of the effect of active dietary counselling was 37% at 3 months (95%CI: 21-54%) and 35% at 24 months (95%CI: 17-53%). Mean fat intake was halved at 3 months and 24 months in Group 1 only. Conclusion: Demonstrating such feasibility is a key step towards defining diet's role in the secondary prevention of breast cancer.© 2011 Elsevier Ltd. All rights reserved.