Comparison of Proteinase Activity, Hemolysin Production, and Adherence Ability of Candida Albicans Isolates Obtained From Gastroesophageal Lesions and Urinary Tract Infections Publisher



Rezvani F¹ ; Maheronnaghsh M¹ ; Mohammadi R^{1, 2}
Source: Journal of Research in Medical Sciences Published:2022

Abstract

Background: Adhesion of Candida to host cell receptors, hemolysin production, and proteinase activity are assumed as principal virulence factors and infection establishment. These virulence factors are essential for colonization, biofilm formation, and attack on the host cells. Materials and Methods: A total of 97 Candida albicans isolates obtained from gastroesophageal lesions and urinary tract infections were included in the study. Adhesion assay, proteinase activity, and hemolysin production were measured. Statistical analysis was performed using the independent t‑test and Chi‑square test to compare quantitative and qualitative data between the two groups. Results: The adherence ability to the buccal epithelial cells was the same in the two groups. Proteinase activity was seen in all clinical isolates. Hemolytic activities were not statistically significant in the two groups. Conclusion: Our results recommend that the pathogenicity of C. albicans in the mucous membranes cannot be connected to the infected site. © 2022 Journal of Research in Medical Sciences | Published by Wolters Kluwer - Medknow.