The Effect of Different Solvent Systems on Physical Properties of Electrospun Poly(Glycerol Sebacate)/Poly(E-Caprolactone) Blend Publisher

Summary: Study finds CF-AC solvent improves PGS/PCL scaffold uniformity, mechanical strength, & pore size for tissue engineering. #Biomaterials #Electrospinning

Atari M^{1, 2} ; Mohammadalizadeh Z³ ; Zargar Kharazi A^{2, 3} ; Haghjooy Javanmard S²
Source: Polymer-Plastics Technology and Materials Published:2022

Abstract

Solvent type and solution viscosity are of great importance in affecting different traits of the electrospun scaffolds. This study aims to highlight the effect of different solvents on physicomechanical properties of PGS/PCL blend electrospun scaffolds. The PGS:PCL (2:1) blends were dissolved in five different solvent systems including DMF, DCM, DMSO, CF-AC, and CF-EtOH, with the final concentration of 18% w/v. Analyzing morphology indicated a more uniform fiber diameter and smaller pore size in PGS/PCL//CF-AC scaffolds. Also, the mechanical parameters were improved by the solvent upon using CF-AC more than DMF, correlated to better solution viscosity, spinnability and uniform fiber distribution. © 2022 Taylor & Francis.