A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor

A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor Publisher Pubmed

Faranoush M¹ ; Abolghasemi H² ; Mahboudi F³ ; Toogeh G⁴ ; Karimi M⁵ ; Eshghi P² ; Managhchi M⁴ ; Hoorfar H⁶ ; Dehdezi BK⁷ ; Mehrvar A⁸ ; Khoeiny B⁹ ; Vaziri B³ ; Kamyar K⁹ ; Heshmat R⁴ Show All Authors

Faranoush M¹
Abolghasemi H²
Mahboudi F³
Toogeh G⁴
Karimi M⁵
Eshghi P²
Managhchi M⁴
Hoorfar H⁶
Dehdezi BK⁷
Mehrvar A⁸
Khoeiny B⁹
Vaziri B³
Kamyar K⁹
Heshmat R⁴
Baghaeipour MR¹⁰
Mirbehbahani NB¹¹
Fayazfar R¹²
Ahmadinejad M¹³
Naderi M¹⁴

Source: Clinical and Applied Thrombosis/Hemostasis Published:2016

Abstract

Introduction: This study compared the efficacy of Aryoseven with Novoseven to control bleeding episodes in patients with hemophilia A with inhibitors. Methods: Sixty-six patients were randomized into 2 groups, with 4 consecutive block randomization. These groups received Aryoseven and Novoseven dosages of 90 to 120 μg/kg intravenously every 2 hours. Results: Median (interquartile range) level of factor VIII (FVIII) inhibitor in groups A and B was 15.0 and 19.0 Bethesda Unit (BU) preadministration. Bleeding onset in group A was 1246 ± 1104 minutes and in group B was 2301 ± 1693 minutes (P =.311). The Kavakli global response scores and treatment success rate was comparable in both the groups. The side effects in groups A (9.7%) and B (2.9%) were comparable. Conclusion: Biosimilar recombinant activated FVII is found to be as effective as Novoseven in the treatment of acute joint bleeding in patients with hemophilia with inhibitors. Its usage will decrease the gaps in hemophilia. © SAGE Publications.

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Majid Ghanavat (1)

Farshad Roghani (1)

Style	Citing Format
MLA	Faranoush M, et al.. "A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor." Clinical and Applied Thrombosis/Hemostasis, vol. 22, no. 2, 2016, pp. 184-190.
APA	Faranoush M, Abolghasemi H, Mahboudi F, Toogeh G, Karimi M, Eshghi P, Managhchi M, Hoorfar H, Dehdezi BK, Mehrvar A, Khoeiny B, Vaziri B, Kamyar K, Heshmat R, Baghaeipour MR, Mirbehbahani NB, Fayazfar R, Ahmadinejad M, Naderi M (2016). A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor. Clinical and Applied Thrombosis/Hemostasis, 22(2), 184-190.
Chicago	Faranoush M, Abolghasemi H, Mahboudi F, Toogeh G, Karimi M, Eshghi P, Managhchi M, et al.. "A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor." Clinical and Applied Thrombosis/Hemostasis 22, no. 2 (2016): 184-190.
Harvard	Faranoush M et al. (2016) 'A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor', Clinical and Applied Thrombosis/Hemostasis, 22(2), pp. 184-190.
Vancouver	Faranoush M, Abolghasemi H, Mahboudi F, Toogeh G, Karimi M, Eshghi P, et al.. A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor. Clinical and Applied Thrombosis/Hemostasis. 2016;22(2):184-190.
BibTex	@article{ author = {Faranoush M and Abolghasemi H and Mahboudi F and Toogeh G and Karimi M and Eshghi P and Managhchi M and Hoorfar H and Dehdezi BK and Mehrvar A and Khoeiny B and Vaziri B and Kamyar K and Heshmat R and Baghaeipour MR and Mirbehbahani NB and Fayazfar R and Ahmadinejad M and Naderi M}, title = {A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor}, journal = {Clinical and Applied Thrombosis/Hemostasis}, volume = {22}, number = {2}, pages = {184-190}, year = {2016} }
RIS	TY - JOUR AU - Faranoush M AU - Abolghasemi H AU - Mahboudi F AU - Toogeh G AU - Karimi M AU - Eshghi P AU - Managhchi M AU - Hoorfar H AU - Dehdezi BK AU - Mehrvar A AU - Khoeiny B AU - Vaziri B AU - Kamyar K AU - Heshmat R AU - Baghaeipour MR AU - Mirbehbahani NB AU - Fayazfar R AU - Ahmadinejad M AU - Naderi M TI - A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor JO - Clinical and Applied Thrombosis/Hemostasis VL - 22 IS - 2 SP - 184 EP - 190 PY - 2016 ER -

Style

Citing Format

MLA

Faranoush M, et al.. "A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor." Clinical and Applied Thrombosis/Hemostasis, vol. 22, no. 2, 2016, pp. 184-190.

APA

Faranoush M, Abolghasemi H, Mahboudi F, Toogeh G, Karimi M, Eshghi P, Managhchi M, Hoorfar H, Dehdezi BK, Mehrvar A, Khoeiny B, Vaziri B, Kamyar K, Heshmat R, Baghaeipour MR, Mirbehbahani NB, Fayazfar R, Ahmadinejad M, Naderi M (2016). A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor. Clinical and Applied Thrombosis/Hemostasis, 22(2), 184-190.

Chicago

Faranoush M, Abolghasemi H, Mahboudi F, Toogeh G, Karimi M, Eshghi P, Managhchi M, et al.. "A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor." Clinical and Applied Thrombosis/Hemostasis 22, no. 2 (2016): 184-190.

Harvard

Faranoush M et al. (2016) 'A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor', Clinical and Applied Thrombosis/Hemostasis, 22(2), pp. 184-190.

Vancouver

Faranoush M, Abolghasemi H, Mahboudi F, Toogeh G, Karimi M, Eshghi P, et al.. A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor. Clinical and Applied Thrombosis/Hemostasis. 2016;22(2):184-190.

BibTex

@article{ author = {Faranoush M and Abolghasemi H and Mahboudi F and Toogeh G and Karimi M and Eshghi P and Managhchi M and Hoorfar H and Dehdezi BK and Mehrvar A and Khoeiny B and Vaziri B and Kamyar K and Heshmat R and Baghaeipour MR and Mirbehbahani NB and Fayazfar R and Ahmadinejad M and Naderi M}, title = {A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor}, journal = {Clinical and Applied Thrombosis/Hemostasis}, volume = {22}, number = {2}, pages = {184-190}, year = {2016} }

RIS

TY - JOUR
AU - Faranoush M
AU - Abolghasemi H
AU - Mahboudi F
AU - Toogeh G
AU - Karimi M
AU - Eshghi P
AU - Managhchi M
AU - Hoorfar H
AU - Dehdezi BK
AU - Mehrvar A
AU - Khoeiny B
AU - Vaziri B
AU - Kamyar K
AU - Heshmat R
AU - Baghaeipour MR
AU - Mirbehbahani NB
AU - Fayazfar R
AU - Ahmadinejad M
AU - Naderi M
TI - A Comparison of Efficacy Between Recombinant Activated Factor Vii (Aryoseven) and Novoseven in Patients With Hereditary Fviii Deficiency With Inhibitor
JO - Clinical and Applied Thrombosis/Hemostasis
VL - 22
IS - 2
SP - 184
EP - 190
PY - 2016
ER -

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Authors

Abstract