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Convenient Synthesis of Novel Chalcone and Pyrazoline Sulfonamide Derivatives As Potential Antibacterial Agents Publisher



Bonakdar APS1 ; Sadeghi A1 ; Aghaei HR1 ; Beheshtimaal K2 ; Nazifi SMR3 ; Massah AR1
Authors

Source: Russian Journal of Bioorganic Chemistry Published:2020


Abstract

Abstract: Novel chalcone sulfonamide derivatives were synthesized starting from benzophenones and aldehydes in 3 steps. Also, (E)-3-(4-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one was converted to different pyrazoline in four steps. The synthesis of sulfonamides was carried out under solvent-free conditions at room temperature and the products were obtained in high purity after a simple work-up without using any chromatography method for purification. All of the products were evaluated for their in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli. © 2020, Pleiades Publishing, Ltd.
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