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Evaluation of Exosomal Mir-155, Let-7G and Let-7I Levels As a Potential Noninvasive Biomarker Among Refractory/Relapsed Patients, Responsive Patients and Patients Receiving R-Chop Publisher Pubmed



Zare N1 ; Haghjooy Javanmard S2 ; Mehrzad V3 ; Eskandari N4 ; Kefayat A5
Authors

Source: Leukemia and Lymphoma Published:2019


Abstract

This study aimed to investigate and compare exosomal miR-155, let-7g and let-7i levels as a noninvasive biomarker among patients with refractory/relapsed or responsive DLBCL after R-CHOP treatment and patients receiving R-CHOP. Plasma was collected and exosomes were isolated from plasma. Exosomes confirmed by zeta-seizer, electron microscope, and western blot. Exosomes concentration was investigated by BCA assay. MiR-155, let-7g and let-7i levels were evaluated in plasma-derived exosomes by real-time PCR. Plasma IFN-γ and IL-4 level were measured by ELISA assay. We observed the significant increase in the exosomal miR-155 levels (p =.002) and exosomes concentration (p =.001) in refractory/relapsed patients compared to responsive patients and patients receiving R-CHOP. No association was not observed between exosomal miR-155 levels and IPI and disease stage. The significant decrease in IFN-γ levels was observed in patients receiving R-CHOP compared to refractory/relapsed or responsive patients (p=.001). Therefore, exosomal miR-155 might be useful as potential prognostic biomarkers to predict response to treatment in DLBCL patients. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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