Peripheral Neuropathy in Type 2 Diabetes Mellitus in Isfahan, Iran: Prevalence and Risk Factors Publisher



Janghorbani M^{1, 2} ; Rezvanian H¹ ; Kachooei A¹ ; Ghorbani A¹ ; Chitsaz A¹ ; Izadi F¹ ; Amini M¹
Source: International Journal of Diabetes and Metabolism Published:2006

Abstract

Background: To estimate the prevalence and risk factors of peripheral neuropathy (PN) in people with type 2 diabetes mellitus. Methods: 810 patients with type 2 diabetes (289 male and 521 female) from Isfahan Endocrinology and Metabolism Research Centre outpatient clinics, Iran , were examined. Part of the examination included an assessment of neurological function including neuropathic symptoms and physical signs, and nerve conduction velocity. Results: The prevalence of PN was 75.1% (95% confidence interval (CI) 72.1, 78.0). Peripheral neuropathy was associated with age, proteinuria, and duration of diabetes, insulin-treatment, and presence of retinopathy and ischaemic heart disease (IHD). The age-adjusted prevalence rate of PN was 78% higher among patients with IHD, 64% higher among patients with any retinopathy, 66% higher among insulin-treated type 2 diabetes, and greater with duration of diabetes. Using a stepwise binary logistic regression model, age, duration of diabetes and proteinuria were significant independent predictors of PN. Conclusion: PN is a common complication in this population of Iranian type 2 diabetic patients. It increases with age, duration of diabetes and proteinuria.