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Molecular Mechanisms of Drug Resistance in Ovarian Cancer Publisher Pubmed

Summary: A review outlines how ovarian cancer cells resist drugs, pointing to new molecular targets for improving treatment. #CancerResearch #OvarianCancer

Norouzibarough L1 ; Sarookhani MR2 ; Sharifi M3 ; Moghbelinejad S4 ; Jangjoo S5 ; Salehi R3
Authors

Source: Journal of Cellular Physiology Published:2018


Abstract

Ovarian cancer is the most lethal malignancy among the gynecological cancers, with a 5-year survival rate, mainly due to being diagnosed at advanced stages, recurrence and resistance to the current chemotherapeutic agents. Drug resistance is a complex phenomenon and the number of known involved genes and cross-talks between signaling pathways in this process is growing rapidly. Thus, discovering and understanding the underlying molecular mechanisms involved in chemo-resistance are crucial for management of treatment and identifying novel and effective drug targets as well as drug discovery to improve therapeutic outcomes. In this review, the major and recently identified molecular mechanisms of drug resistance in ovarian cancer from relevant literature have been investigated. In the final section of the paper, new approaches for studying detailed mechanisms of chemo-resistance have been briefly discussed. © 2017 Wiley Periodicals, Inc.
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