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In Vivo Pharmacokinetics, Bio-Distribution and Anti-Tumor Activity of Docetaxel-Loaded Folate Targeted Biocompatible Polymeric Micelles Publisher Pubmed

Summary: Can targeted micelles improve chemotherapy delivery? A preclinical study found folate-guided docetaxel carriers improved tumor targeting; human benefits remain unproven. #DrugDelivery #Cancer

Kazemi M ; Emami J ; Hasanzadeh F ; Minaiyan M ; Mirian M ; Lavasanifar A
Authors

Source: Cancer Investigation Published:2026


Abstract

Anti-tumor agent, docetaxel (DTX), was incorporated into novel pre-synthesized pH-triggered folate-targeted polymeric micelles to overcome insufficient drug accumulation at the tumor site and to reduce side effects in healthy tissues. Tumor growth inhibition rate (87.8%), elimination half-life (7.15 h), and tumor targeting efficiency (74.3%) for the targeted micellar formulation were significantly improved compared to those of free DTX (52.14%, 4.98 h, and 52.92% respectively). Overall, the findings of the current study showed that folate-targeted micelle is a potential targeting drug delivery system improving the efficacy of anticancer drugs through selective targeting of tumor tissues. © 2026 Taylor & Francis Group, LLC.
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In Vivo Pharmacokinetics, Bio-Distribution and Anti-Tumor Activity of Docetaxel-Loaded Folate Targeted Biocompatible Polymeric Micelles
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