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New Mirsinane-Type Diterpenes From Euphorbia Microsciadia Boiss. With Inhibitory Effect on Vegf-Induced Angiogenesis Publisher Pubmed



Ghanadian SM1 ; Ayatollahi AM2 ; Afsharypuor S3 ; Javanmard SH4 ; Dana N4
Authors

Source: Journal of Natural Medicines Published:2013


Abstract

Euphorbia microsciadia (Euphorbiaceae) is a perennial plant growing in Iran. Two new cyclomyrsinol esters, 3-O-propionyl-5, 10, 14-O-triacetyl-8-O- (2′-methyl-butanoyl)-cyclomyrsinol (1) and 3, 5, 10, 14, 15-O-pentaacetyl-8-O-isobutanoyl-cyclomyrsinol (2) were isolated from the methanolic extract of its dried aerial parts. The structures were elucidated based on 13C- and 1H-NMR as well as 2D-NMR, IR and different MS spectra. Anti-angiogenic activity was also evaluated on vascular endothelium growth factor (VEGF)-induced angiogenesis in cultured human umbilical vein endothelial cells in vitro by assessing capillary-like tube network formation. © 2012 The Japanese Society of Pharmacognosy and Springer.
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