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Solvent-Free Synthesis, Adme Prediction, and Evaluation of Antibacterial Activity of Novel Sulfonamide Derivatives Publisher



Rafiee Pour Z1 ; Nazifi SMR2 ; Afshari Safavi A3 ; Nazifi ZS1 ; Massah AR1, 4
Authors

Source: Russian Journal of Organic Chemistry Published:2019


Abstract

A series of novel sulfonamides containing a 2-amino-1,3-thiazole fragment have been synthesized using a simple and efficient method under solvent-free conditions. The obtained N-(4-sulfamoyl-1,3-thiazol-2-yl)-4-nitrobenzamides were evaluated for their antibacterial activity against S. aureus and E. coli, and in silico ADME prediction was performed to find biological behavior. © 2019, Pleiades Publishing, Ltd.
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