Non-Coding Rnas and Neurodegenerative Diseases: Information of Their Roles in Apoptosis Publisher Pubmed



Valizadeh M¹ ; Derafsh E² ; Abdi Abyaneh F³ ; Parsamatin SK⁴ ; Noshabad FZR⁵ ; Alinaghipour A⁶ ; Yaghoobi Z^{7, 8} ; Taheri AT⁹ ; Dadgostar E^{10, 11} ; Aschner M¹² ; Mirzaei H¹³ ; Tamtaji OR^{7, 8} ; Nabavizadeh F^{7, 8}
Source: Molecular Neurobiology Published:2024

Abstract

Apoptosis can be known as a key factor in the pathogenesis of neurodegenerative disorders. In disease conditions, the rate of apoptosis expands and tissue damage may become apparent. Recently, the scientific studies of the non-coding RNAs (ncRNAs) has provided new information of the molecular mechanisms that contribute to neurodegenerative disorders. Numerous reports have documented that ncRNAs have important contributions to several biological processes associated with the increase of neurodegenerative disorders. In addition, microRNAs (miRNAs), circular RNAs (circRNAs), as well as, long ncRNAs (lncRNAs) represent ncRNAs subtypes with the usual dysregulation in neurodegenerative disorders. Dysregulating ncRNAs has been associated with inhibiting or stimulating apoptosis in neurodegenerative disorders. Therefore, this review highlighted several ncRNAs linked to apoptosis in neurodegenerative disorders. CircRNAs, lncRNAs, and miRNAs were also illustrated completely regarding the respective signaling pathways of apoptosis. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.