The Effects of 6-Gingerol on Reproductive Improvement, Liver Functioning and Cyclooxygenase-2 Gene Expression in Estradiol Valerate – Induced Polycystic Ovary Syndrome in Wistar Rats Publisher Pubmed



Pournaderi PS¹ ; Yaghmaei P¹ ; Khodaei H² ; Noormohammadi Z¹ ; Hejazi SH³
Source: Biochemical and Biophysical Research Communications Published:2017

Abstract

6-Gingerol is the major pungent ingredient of ginger with anti-inflammatory and antioxidant properties. In this study, we evaluate the effects of 6-gingerol on the biochemical parameters and ovarian histological improvements in estradiol valerate (EV) induced PCOS rats. Thirty six female Wistar rats were divided into 4 groups: control, received normal diet, PCOS control, received 4 mg/kg EV injection for 28 days and two experimental groups, received an EV injection for 28 days and followed by 6-gingerol (200 μg/kg and 400 μg/kg) for 14 days. The administration of EV led to increase body and ovarian weights, abnormality in serum sex steroid profile, decrease in antioxidant activity and increase in COX-2 gene expression. 6-gingerol treatments, particularly the 400 μg/kg dose, markedly attenuated these alterations. 6-gingerol showed beneficial effects in the EV induced PCOS rats via decreased expression of COX-2, restored biochemical parameters to normal and decreased of cysts in the ovaries. © 2017 Elsevier Inc.