Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Assessment of Superparamagnetic Iron Oxide Nanoparticles Conjugated With Anti-Epidermal Growth Factor Receptor Antibody for the Detection of Lung Cancer by Magnetic Resonance Imaging (Mri) in C57bl/6 Publisher

Summary: Scientists report magnetic nanoparticles target lung cancer cells for better MRI detection with low toxicity. #CancerDetection #Nanotechnology

Abdi N1 ; Shahbazigahrouei D1
Authors

Source: Journal of Isfahan Medical School Published:2021


Abstract

Background: In this study, superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with anti-epidermal growth factor receptor antibody (anti-EGFR-SPIONs) were used as a targeted contrast agent in magnetic resonance imaging (MRI) in mice. Methods: This was an experimental intervention, performed on 25 C57BL/6 healthy and cancerous mice on LL/2 (LLC1) cell line. Atomis absorption spectrophotometry (AAS) was used to determine of iron content in tumor and other studied tissues and MRI scanner was applied for MR imaging signal intensity under in-vivo conditions. Findings: The results of AAS showed a good iron uptake using specific antibody in the tumor compared to other organs. Moreover, image signal intensity findings revealed its targeted diagnosis for lung cancer LLC1 cells. Conclusion: Designed nanoprobes may be used as a diagnostic agent in detection of target cells and as a contrast agent for targeted magnetic resonance imaging of these cells. © 2021 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. In Vivo Study of Anti-Epidermal Growth Factor Receptor Antibody-Based Iron Oxide Nanoparticles (Anti-Egfr-Spions) As a Novel Mr Imaging Contrast Agent for Lung Cancer (Llc1) Cells Detection, IET Nanobiotechnology (2020)
2. Recent Nanotheranostics Applications for Cancer Therapy and Diagnosis: A Review, IET Nanobiotechnology (2021)
3. Porphyrin–Iron Oxide Nanoparticle Functionalized With Trastuzumab (Ion–Pp–Tz) Potential Mr Imaging Probe for Breast Cancer Cells, Applied Physics A: Materials Science and Processing (2022)
Experts (# of related papers)
View all Related Experts
Daryoush Shahbazi-Gahrouei (20)
Seyed Hossein Hejazi (4)
Assessment of Superparamagnetic Iron Oxide Nanoparticles Conjugated With Anti-Epidermal Growth Factor Receptor Antibody for the Detection of Lung Cancer by Magnetic Resonance Imaging (Mri) in C57bl/6
Other Related Docs
4. Study the Anti-Muc1 Antibody-Based Iron Oxide Nanoparticles on Three-Dimension Spheroid and Breast Cancer (Mcf-7) Cell Imaging, Polish Journal of Medical Physics and Engineering (2019)
5. Superparamagnetic Iron Oxide-C595: Potential Mr Imaging Contrast Agents for Ovarian Cancer Detection, Journal of Medical Physics (2013)
6. Detection of Muc1-Expressing Ovarian Cancer by C595 Monoclonal Antibody-Conjugated Spions Using Mr Imaging, The Scientific World Journal (2013)
7. Assessment of Manganese-Zinc Ferrite Nanoparticles As a Novel Magnetic Resonance Imaging Contrast Agent for the Detection of 4T1 Breast Cancer Cells, Journal of Medical Signals and Sensors (2019)
8. Magnetic Iron Oxide Nanoparticles As T2 Mr Imaging Contrast Agent for Detection of Breast Cancer (Mcf-7) Cell, Avicenna Journal of Medical Biotechnology (2017)
9. Synthesis and Characterisation of Iron Oxide Nanoparticles Conjugated With Epidermal Growth Factor Receptor (Egfr) Monoclonal Antibody As Mri Contrast Agent for Cancer Detection, IET Nanobiotechnology (2019)
10. Breast Cancer Cell Targeted Mr Molecular Imaging Probe: Anti-Muc1 Antibody-Based Magnetic Nanoparticles, Journal of Physics: Conference Series (2017)
11. Chitosan–Imidazolium Core–Shell Nanoparticles of Gd-Mn-Mo Polyoxometalate As Novel Potential Mri Nano-Agent for Breast Cancer Detection, Micromachines (2023)
12. A Novel Method for Quantitative Analysis of Anti-Mucl Expressing Ovarian Cancer Cell Surface Based on Magnetic Cell Separation, Journal of Medical Sciences (Faisalabad) (2012)
13. In Vitro Study of Spions-C595 As Molecular Imaging Probe for Specific Breast Cancer (Mcf-7) Cells Detection, Iranian Biomedical Journal (2017)
14. A Literature Review on Multimodality Molecular Imaging Nanoprobes for Cancer Detection, Polish Journal of Medical Physics and Engineering (2019)
15. Synthesis and in Vitro Evaluation of Mr Molecular Imaging Probes Using J591 Mab-Conjugated Spions for Specific Detection of Prostate Cancer, Contrast Media and Molecular Imaging (2013)
16. Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent, International Journal of Polymeric Materials and Polymeric Biomaterials (2021)
17. Aptamer-Conjugated Magnetic Nanoparticles As Targeted Magnetic Resonance Imaging Contrast Agent for Breast Cancer, Journal of Medical Signals and Sensors (2016)
18. Synthesis and Application of Fe3o4@Au Composite Nanoparticles As Magnetic Resonance/Computed Tomography Dual-Modality Contrast Agent, Journal of Medical Signals and Sensors (2020)
19. Cobalt Zinc Ferrite Nanoparticles As a Potential Magnetic Resonance Imaging Agent: An in Vitro Study, Avicenna Journal of Medical Biotechnology (2015)
20. Novel Mr Imaging Nanoprobe for Hepatocellular Carcinoma Detection Based on Manganese–Zinc Ferrite Nanoparticles: In Vitro and in Vivo Assessments, Journal of Cancer Research and Clinical Oncology (2023)