Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Synthesis and Cytotoxic Evaluation of Some New 4(3H)-Quinazolinones on Hela Cell Line



Khodarahmi GA1 ; Shamshiri M1 ; Hassanzadeh F1
Authors

Source: Research in Pharmaceutical Sciences Published:2012

Abstract

Quinazolinone backbone is present in a large number of bioactive substances. Since remarkable cytotoxic activity is associated with some 4(3H)-quinazolinones, in this study some 4(3H)-quinazolinone were synthesized and screened against HeLa cells. The synthesis was performed via reaction of anthranilic acid with dicarboxylic anhydrides to produce carboxylic acids derivatives. The products were heated in acetic anhydride to produce benzoxazinones. Finally, 4(3H)-quinazolinones were synthesized by reaction between benzoxazinones and primary amines. The assessment of the structure of the synthesized compounds was based on spectral data (FT-IR, Mass and 1HNMR). Subsequently, cytotoxic activity of compounds 3, 6, 9 and 13 (individually and in combination with doxorubicin) was evaluated on HeLa cell line using MTT assay. The results indicated that the tested compounds did not show significant cytotoxicity alone and in combination with doxorubicin (1 and 20 μM).
Other Related Docs
4. Synthesis of Some New Tricyclic 4(3H)-Quinazolinone Derivatives, Research in Pharmaceutical Sciences (2011)
11. Quinazolinone-Based Hybrids With Diverse Biological Activities: A Mini-Review, Journal of Research in Medical Sciences (2022)
20. Synthesis and Antifungal Activity Evaluation of a Fluconazole Analog Derived From Dithiocarbamate, Journal of Mazandaran University of Medical Sciences (2024)