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Effect of Eplerenone Treatment in Patients With Central Serous Retinopathy: A Double‑Blind Randomized Clinical Trial Publisher



Akhlaghi M1 ; Dehghani A1 ; Kianersi F1 ; Khalili MR2 ; Tohidi M1 ; Jahanbaniardakani H2
Authors

Source: Journal of Current Ophthalmology Published:2024


Abstract

Purpose: To evaluate the efficacy of eplerenone in central serous chorioretinopathy (CSCR) patients in a clinical trial design. Methods: In this double‑blind clinical trial, naive acute CSCR patients were divided into two groups: treatment with eplerenone 25 mg daily in the 1st week followed by 50 mg for the next 3 weeks and placebo group. Best‑corrected visual acuity (BCVA), central macular thickness (CMT), macular volume (MV), and choroidal thickness (CT) were measured before and after 1 month of the intervention using the optical coherence tomography technique. Results: Thirty‑one CSCR (male: 23, female: 8) and 25 CSCR patients (male: 18, female: 7) with the mean age of 35.65 ± 5.94 and 37.08 ± 6.41 years were recruited and divided randomly into treatment and placebo groups, respectively. BCVA improved significantly in the treatment group (from 0.28 ± 0.26 to 0.11 ± 0.14, P = 0.002) compared with the placebo group (from 0.31 ± 0.26 to 0.21 ± 0.14, P = 0.052). Although CT, CMT, and MV improved significantly in each group, there were no significant differences between the groups. Conclusion: In this study, we found favorable short‑term clinical effects of eplerenone in acute CSCR patients, showing the pivotal role of mineralocorticoid receptors in the retina. © 2024 Journal of Current Ophthalmology.
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