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3-Keto Umbilicagenin a and B, New Sapogenins From Allium Umbilicatum Boiss Publisher Pubmed



Sadeghi M1 ; Zolfaghari B1 ; Troiano R2 ; Lanzotti V2
Authors

Source: Fitoterapia Published:2015


Abstract

Two sapogenins, named 3-keto umbilicagenin A and B (1 and 2), possessing a novel chemical structure with a 3-keto group on the spirostane skeleton, have been isolated from Allium umbilicatum Boiss. Their chemical structure has been established through a combination of extensive spectroscopic analysis, mainly nuclear magnetic resonance and mass spectrometry, and chemical methods as (25R)-3-keto-spirostan-2α,5α,6β-triol (1) and (25R)-3-keto-spirostan-2α,5α-diol (2). The isolated compounds were tested for cytotoxic activity on J-774, murine monocyte/macrophage, and WEHI-164, murine fibrosarcoma cell lines. © 2015 Elsevier B.V. All rights reserved.
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