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Impact of Oral Administration of Calcitriol to Prevent Symptomatic Hypocalcemia After Total Thyroidectomy: Systematic Review and Meta-Analysis Publisher Pubmed

Summary: Pre-operative calcitriol may boost calcium levels post-thyroidectomy, reducing hypocalcemia risk, but results vary, study suggests. #ThyroidSurgery #CalciumHealth

Dadkhah PA1 ; Farshid A2 ; Khademi R3 ; Yaghoubi S4 ; Asadzadeh A5 ; Moharamnejad N2 ; Jadidian F6 ; Ziaei SA7 ; Haghshoar S8 ; Salimi O9 ; Shafagh SG10 ; Rabiei N11 ; Shahsavari S12 ; Shokravi S13 Show All Authors
Authors
  1. Dadkhah PA1
  2. Farshid A2
  3. Khademi R3
  4. Yaghoubi S4
  5. Asadzadeh A5
  6. Moharamnejad N2
  7. Jadidian F6
  8. Ziaei SA7
  9. Haghshoar S8
  10. Salimi O9
  11. Shafagh SG10
  12. Rabiei N11
  13. Shahsavari S12
  14. Shokravi S13
  15. Maroufi Z14
  16. Deravi N15
  17. Erabi G16
  18. Naziri M17

Source: Scandinavian Journal of Surgery Published:2024


Abstract

Background: One of the most common complications of total thyroidectomy is post-operative transient or persistent hypoparathyroidism that can cause symptomatic hypocalcaemia. To prevent this complication, shorten the period of hospitalization and reduce morbidity, routine supplementation of oral vitamin D and calcium has been suggested. This systematic review and meta-analysis aims to critically assess the association between pre-operative calcitriol supplementation and post-operative hypocalcaemia. Methods: Randomized controlled trial studies were identified by searching PubMed, Scopus, and Google Scholar databases up to 30 March 2023. Screening of titles, abstracts, and full texts of articles were performed, and data were extracted for a meta-analysis. Results: This meta-analysis includes data from nine randomized controlled trials with a total of 1259 patients but with significant heterogeneity. The results demonstrate that calcium levels were higher in patients who had pre-operative calcitriol supplementation, with a weighted mean difference (WMD) 0.18 (95% confidence interval (CI) = 0.00, 0.37). Pre-operative calcitriol supplementation did not lead to significant changes in parathyroid hormone (PTH) levels, with WMD −0.49 (95% CI: −1.91, 0.94). Conclusion: Pre-operative calcitriol supplementation leads to higher calcium levels, but the high heterogeneity of the included studies (79% to 98.7%) could affect the results. © The Finnish Surgical Society 2024.
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